2041 Do linear and volumetric measures of left ventricular concentricity agree?
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Meeting abstract
2041 Do linear and volumetric measures of left ventricular concentricity agree? Carol J Salton*1, Noriko Oyama1, Daniel Levy2, Elizabeth A Goddu1, Christopher J O'Donnell2, Warren J Manning1 and Michael L Chuang1 Address: 1Beth Israel Deaconess Medical Center, Boston, MA, USA and 2The NHLBI's Framingham Heart Study, Framingham, MA, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A310
doi:10.1186/1532-429X-10-S1-A310
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A310 © 2008 Salton et al; licensee BioMed Central Ltd.
Introduction Increased left ventricular (LV) mass is an independent predictor of cardiovascular morbidity and mortality. Concentric LV geometry confers excess cardiac risk above that of increased LV mass alone. Concentricity is traditionally defined as an increased ratio of inferior wall thickness (IWT) to end-diastolic dimension (EDD, or LV diameter). This relative wall thickness (RWT) is determined using linear measurements at a single level of the ventricle and may not accurately reflect the relationship between LV mass and cavity size in the presence of focal abnormalities.
Purpose Determine whether a volumetric extension of RWT, the ratio of LV mass to end-diastolic volume (EDV) ranks subjects in the same manner as RWT, particularly as many recent reports present the ratio of LV mass to EDV as a volumetric measure of concentricity.
Methods Data from 200 adults (100 consecutively-scanned men and 100 consecutive women), aged 61 ± 8 years, from the Framingham Offspring cohort were analyzed for this study. Subjects underwent contiguous multislice ECGgated SSFP breathhold cine CMR imaging in the LV shortaxis orientation in a 1.5-T scanner using cardiac array coil for RF signal reception. Imaging parameters included a slice thickness of 10 mm without gap and in-plane resolution of 1.92 × 1.56 mm2. RWT was defined in the standard manner as 2 × IWT/EDD, with measurements taken from
a short-axis slice just basal to the papillary muscle tips. "Relative total mass" or RTM was defined as the ratio of LV mass to EDV. Continuous variables are summarized as mean ± SD. Differences between sexes were assessed by unpaired, 2-tailed t test, with p < 0.05 considered significant. On further analysis, subjects, divided by sex, were ranked by RWT and by RTM. We used Spearman correlation to assess agreement between linear (RWT) and volumetric (RTM) rankings. We also divided subjects into quartiles of concentricity by RWT and by RTM and tabulated the number of between-quartile changes when comparing the two measures, where Q0 indicates the same quartile (zero change), Q1
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