7.4 Early Cardiac Damage in High Cardiovascular Risk Patients
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Imaging Techniques 7.4 Early Cardiac Damage in High Cardiovascular Risk Patients A.C.M Capra (1), M. Galderisi (2), C. Giannattasio (1), D. Dozio (1), P. Canova (1), F. Soriano (1), P. Innelli (2), A.A. Turco (2), S. Turco (2), P. Campadello (1), F. Paleari (3), O. De Divitiis (2), G. Mancia (1) ` di Napoli “Federico II”, (1)Universita Milano Bicocca, Monza, Italy, (2)Universita Napoli, Italy, (3)Ospedale San Gerardo, Monza, Italy Introduction. Diabetes is often associated with left ventricular hypertrophy, but it is not known if functional impairment, especially diastolic impairment, can be present also without left ventricular hypertrophy. Aim. To investigate diastolic dysfunction in diabetic patients without echographic assessed cardiac hypertrophy. Methods. 53 subjects were studied. Among those patients, 24 were type 2 diabetic normotensive patients (group A), 16 type 2 diabetic hypertensive patients (group B) and 13 were sex and age matched healthy controls (group C). All diabetics assumed metformin and all hypertensives assumed Ace inhibitors. In each subject we performed an echocardiographic evaluation of diastolic function (E/ A and Dec time) including Tissue Doppler analysis of lateral (L) mitral annulus. Data collection included the glycometabolic profile, blood pressure and body mass index. Results. Blood pressure, body mass index, blood glucose and insulin resistance all showed higher values in group B than in group A and C. (BMI: 31±0.8 vs 26.9± 0.6 and 25.0±.6 kg/m2 respectively, p
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