A miRNome analysis of drug-free manic psychotic bipolar patients versus healthy controls
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ORIGINAL PAPER
A miRNome analysis of drug‑free manic psychotic bipolar patients versus healthy controls Silvia Tabano1 · Alice Caldiroli2 · Andrea Terrasi1,3 · Patrizia Colapietro1 · Silvia Grassi2 · Greta Silvia Carnevali2 · Laura Fontana1 · Marta Serati2 · Valentina Vaira1,3 · A. Carlo Altamura2 · Monica Miozzo1,3 · Massimiliano Buoli2 Received: 11 February 2019 / Accepted: 7 August 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract The lifetime presence of psychotic symptoms is associated with more clinical severity, poorer outcome and biological changes in patients affected by bipolar disorder (BD). Epigenetic mechanisms have been evoked to explain the onset of psychotic symptoms in BD as well as the associated biological changes. The main objective of the present study was to evaluate the expression profiles of circulating microRNAs (miRNAs) in drug-free manic psychotic bipolar patients versus healthy controls (HC), to identify possible non-invasive molecular markers of the disorder. 15 drug-free manic psychotic bipolar patients and 9 HC were enrolled and 800 miRNAs expression profile was measured by Nanostring nCounter technology on plasma samples and validated through qPCR. Overall, twelve miRNAs showed a significantly altered expression between the two groups (p 1 and a Bonferroni p-adj value
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