A noninvasive index to predict liver cirrhosis in biliary atresia
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ORIGINAL ARTICLE
A noninvasive index to predict liver cirrhosis in biliary atresia Yuan-Heng Mo 1,2 & Huey-Ling Chen 3 & Wen-Ming Hsu 4 & Chin-Hao Chang 5 & Steven Shinn-Forng Peng 2 Received: 16 October 2019 / Revised: 23 May 2020 / Accepted: 20 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Biliary atresia is a progressive obliterative cholangiopathy affecting both extrahepatic and intrahepatic biliary trees, resulting in fibrous obliteration of the biliary tract and subsequent development of cirrhosis. Objective The aim of this study was to find noninvasive indices to predict the status of hepatic fibrosis in children with biliary atresia. Materials and methods We retrospectively measured the volume of the hepatic lobes and spleen from MR images, obtained biochemical data and analyzed the relationship between the imaging and biochemical indices, and the pathological status of hepatic fibrosis in 35 children with biliary atresia. Results A combined index was obtained by logistic regression: logit (likelihood of cirrhosis) = 0.00043 x age at MR examination + 1.67 x aspartate aminotransferase and platelet ratio index (APRI) + 0.0029 x body-surface-area-adjusted left liver lobe volume (BSA adLLV) – 6.57 (log-likelihood chi-square P3.5 g/dL, 2.8–3.5 g/dL,
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