A Prospective Study of the Efficacy of Cell-Assisted Lipotransfer with Stromal Vascular Fraction to Correct Contour Defo
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ORIGINAL ARTICLE
BREAST SURGERY
A Prospective Study of the Efficacy of Cell-Assisted Lipotransfer with Stromal Vascular Fraction to Correct Contour Deformities of the Autologous Reconstructed Breast Hyeon Jun Jeon1 • Dong Hun Choi2 • Jung Ho Lee1 • Joon Seok Lee1 Jeeyeon Lee3 • Ho Yong Park3 • Jung Dug Yang1
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Received: 20 August 2020 / Accepted: 12 September 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2020
Abstract Background Autologous lipotransfer has increasingly become popular for breast reconstruction. Moreover, owing to the emergence of information regarding the efficacy of stromal vascular fraction (SVF) in terms of oncological safety and survival rate, procedures based on cell-assisted lipotransfer (CAL) have been widely employed recently. However, quantitative data of CAL with SVF are lacking. We evaluated the efficacy of CAL using SVF on survival rate in breast reconstruction. Methods A 12-month prospective study was conducted for 20 patients (20 breasts) requiring breast asymmetry correction due to volume deficit following autologous breast reconstruction using a transverse rectus abdominis myocutaneous flap or latissimus dorsi flap after total mastectomy. After the patients were equally divided into two groups—fat graft with SVF (Group 1, n = 10) and without SVF (Group 2, n = 10)—, the variance of breast volume was measured using three-dimensional scanning to analyze fat graft retention rate. Moreover, patient satisfaction and complications were investigated. Results Fat graft retention rate was higher in Group 1 than in Group 2 at both postoperative 6 months (73.8% vs. 62.2%; p = 0.03) and 12 months (65.4% vs. 48.4%;
& Jung Dug Yang [email protected] 1
Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, 130 Dongdeokro, Daegu 41944, Korea
2
Leaders Plastic Surgery Clinic, Daegu, Korea
3
Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Korea
p = 0.03). Group 1 showed higher patient satisfaction. Regarding complications, fat necrosis occurred in 1 patient each in both groups. However, locoregional recurrence was not observed in any patient during follow-up. Conclusions CAL with SVF is effective in increasing survival rates of autologous fat grafts for correction of volume deficit after breast reconstruction. Moreover, it is associated with improved patient satisfaction in terms of the esthetic aspect. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 Keywords Autologous lipotransfer Stromal vascular fraction Breast volumetry Three-dimensional scanning
Introduction In recent years, autologous lipotransfer has widely been used in breast augmentation for simple cosmetic purposes as well as in breast reconstruction using
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