A Study of Two Cases Co-Infected with SARS-CoV-2 and Human Immunodeficiency Virus
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LETTER
A Study of Two Cases Co-Infected with SARS-CoV-2 and Human Immunodeficiency Virus Rong Zhang1 • Xiaohua Chen2 • Yuqing Huang3 • Qi Zhang3 • Yan Cheng4 • Nan Zhang5 • Haibo Zhang6 Bo Yang7 • Fang Liu3 • Yingle Liu3 • Ke Lan3
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Received: 7 May 2020 / Accepted: 13 August 2020 Ó Wuhan Institute of Virology, CAS 2020
Dear Editor, Since December 2019, A new type of coronavirus pneumonia (coronavirus disease 2019, COVID-19) has become endemic in Wuhan, China. So far, COVID-19 has developed into a global epidemic. The body’s immune system plays an important role in the fight against COVID-19. Here, we followed up the clinical data and treatment of two COVID-19 patients diagnosed with acquired immunodeficiency syndrome (AIDS), hoping to be helpful for the subsequent diagnosis and treatment of patients with related diseases. Patient 1, male, 24 years old, unmarried, lived in Hankou Jiangan District, Wuhan City before the onset of the disease, presented with fever symptoms up to 40 °C on February 8, accompanied by fatigue, anorexia, dizziness, and apparent chest tightness and shortness of breath after the exercise.
Rong Zhang, Xiaohua Chen and Yuqing Huang contributed equally to this work.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12250-020-00280-9) contains supplementary material, which is available to authorized users. & Ke Lan [email protected] & Yingle Liu [email protected] & Fang Liu [email protected]
Then he came to our hospital for treatment on the evening of February 20, 2020. The CT scan indicated that double lungs were compromised, suggesting the possibility of viral pneumonia (Supplementary Table S1). He also tested positive for SARS-CoV-2 in his throat’s swab. Patient 1 was admitted to the COVID-19 designated hospital on February 20, with no significant remission from previous treatment. One day after admission (February 21), the patient developed symptoms of sore throat and night sweats, suggesting possible secondary bacterial infections. CT scan on March 2 suggested an increase in double-lung lesions and a risk of disease aggravation. Subsequently, patient 1 developed a high fever during the night on March 3. One day later, on March 4, tocilizumab injection (an IL-6 inhibitor) was started. The hospital began to treat patient 1 with antibiotics due to his antiadoncus on March 8, suggesting nosocomial infection. Because a variety of treatments did not work, three CT scan results of the patient also showed no improvement, the hospital began to consider the impact of immune-related diseases. The blood routine and biochemical results suggested a lymphocytic albumin decrease (Tables 1 and 2). The patient was tested for HIV antibodies and obtain a positive result, which was reported to the Wuhan Center for Disease Control and Prevention for reexamination on March 12. The patient was transferred to a specialized hospital for treatment on March 19, and subsequent reexaminati
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