A three-gene signature and clinical outcome in pediatric acute myeloid leukemia
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RESEARCH ARTICLE
A three‑gene signature and clinical outcome in pediatric acute myeloid leukemia Z. Cai1 · Y. Wu2 · F. Zhang3 · H. Wu2 Received: 28 June 2020 / Accepted: 12 August 2020 © Federación de Sociedades Españolas de Oncología (FESEO) 2020
Abstract Background Although the 5-year survival rates in pediatric acute myeloid leukemia (AML) have improved over the last decades, there is a high relapse rate for Pediatric AML patients. Methods In the present study, we mainly combine PCA with the LASSO technique to identify prognostic markers for Pediatric AML patients coming from the NCI TARGET database. Results Three key genes (EEF1A1, RPLP2, RPL19) associated with poor prognosis of pediatric AML has been screened by both PCA and LASSO Cox regression analysis. Simultaneously, we developed a risk score model to predict the prognosis of pediatric AML, according to risk scores, the patients were divided into high‐ and low‐risk groups based on the median risk score. Kaplan–Meier survival analysis indicated that Pediatric AML patients with the high-risk group have a poorer survival rate than those with a low‐risk group (p
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