Aberrant brain functional hubs and causal connectivity in presbycusis
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ORIGINAL RESEARCH
Aberrant brain functional hubs and causal connectivity in presbycusis Chunhua Xing 1 & Yu-Chen Chen 1 & Zhaopeng Tong 2,3 & Wenchao Xu 2,3 & Jin-Jing Xu 4 & Xindao Yin 1 & Yuanqing Wu 4 & Yuexin Cai 2,3
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract To investigate resting-state connectivity and further understand directional aspects of implicit alterations in presbycusis patients, we used degree centrality (DC) and Granger causality analysis (GCA) to detect functional hubs of the whole-brain network and then analyze directional connectivity. Resting-state functional magnetic resonance imaging (fMRI) scans were performed on 40 presbycusis patients and 40 healthy controls matched for age, gender, and education. We used DC analysis and GCA to characterize abnormal brain networks in presbycusis patients. The associations of network centrality and directed functional connectivity (FC) with clinical measures of presbycusis were also examined according to the above results. We found that the network centrality of left frontal middle gyrus (MFG) was significantly lower than that of healthy control group. Unidirectionally, the left MFG revealed increased directional connectivity to the left superior frontal gyrus (SFG), while the left MFG exhibited decreased directional connectivity to the left middle temporal gyrus (MTG) and right lingual gyrus (LinG). And the decreased directional connectivity was found from the left precentral gyrus (PrCG) to the left MFG. In addition, the Trail-Making Test B (TMT-B) score was negatively correlated with the decreased DC of the left MFG (r = −0.359, p = 0.032). Resting-state fMRI provides a novel method for identifying aberrant brain network architecture. These results primarily indicate altered functional hubs and abnormal frontal lobe connectivity patterns that may further reflect executive dysfunction in patients with presbycusis. Keywords Presbycusis . Degree centrality . Directional connectivity . Resting-state fMRI
Introduction Hearing loss accompanying aging, known as presbycusis, is the very common chronic health condition, mainly affecting the elderly who over 70 years of age with more rapid and Chunhua Xing and Yu-Chen Chen contributed equally to this work. * Yuanqing Wu [email protected] * Yuexin Cai [email protected] 1
Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
2
Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou 510120, China
3
Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
4
Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, Nanjing 210006, China
dominantly occurring in the older adults and in the higher frequencies (Gates and Mills 2005; Rutherford et al. 2018). With the aging of the global population, nearly 35–50% of adults aged 65 years or older suffered from this condition and it is predicted that
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