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D ETLEV G ANTEN . K LAUS R UCKPAUL (Eds.)
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
Professor Dr. Detlev Ganten Charité Campus Charité Mitte Schumannstr. 20/21 10117 Berlin [email protected]
Professor Em. Dr. Klaus Ruckpaul Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch Robert-Rössle-Straße 10 13125 Berlin Germany [email protected]
ISBN-10 3-540-44244-8 Springer Berlin Heidelberg New York ISBN-13 978-3-540-44244-8 Springer Berlin Heidelberg New York This publication is available also as Electronic publication under ISBN-10: 3-540-29623-9/ISBN-13: 978-3-540-29623-2 and Electronic and print bundle under ISBN-10: 3-540-30954-3/ISBN-13: 978-3-540-30954-3 Library of Congress Control Number: 2001012345 Bibliographic information published by Die Deutsche Bibliothek. Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at: http://dnb.ddb.de This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg New York 2006 Printed in Germany The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant literature. Development Editor: Dr. Michaela Bilic, Dr. Natasja Sheriff, Heidelberg Production Editor: Frank Krabbes, Heidelberg Cover design: Frido Steinen-Broo, Girona Printed on acid free paper
SPIN: 10893219
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Preface The development of molecular medicine is closely linked with the rapidly growing knowledge in molecular biology, molecular genetics and genome research. Research findings in these fields have led to a shift in therapeutic targets. Whilst until recently only gene products such as enzymes and cell receptors represented targets of diagnostic processes, today the information carriers DNA and RNA themselves are evolving into target molecules, or medicinal drugs. Alongside researching into interactive processes on a cellular level – drawn from the biochemical advances made in the past century – mutation
