Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles
- PDF / 788,283 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 43 Downloads / 175 Views
SUSCEPTIBILITY FACTORS IN ENVIRONMENTAL HEALTH (Z LIEW AND K POLLITT, SECTION EDITORS)
Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles Kosuke Inoue 1 & Qi Yan 1 & Onyebuchi A. Arah 1,2,3 & Kimberly Paul 1 & Douglas I. Walker 4 & Dean P. Jones 5,6 & Beate Ritz 1,7,8
# Springer Nature Switzerland AG 2020
Abstract Purpose of Review Review how to use metabolomic profiling in causal mediation analysis to assess epidemiological evidence for air pollution impacts on birth outcomes. Recent Findings Maternal exposures to air pollutants have been associated with pregnancy complications and adverse pregnancy and birth outcomes. Causal mediation analysis enables us to estimate direct and indirect effects on outcomes (i.e., effect decomposition), elucidating causal mechanisms or effect pathways. Maternal metabolites and metabolic pathways are perturbed by air pollution exposures may lead to adverse pregnancy and birth outcomes, thus they can be considered mediators in the causal pathways. Metabolomic markers have been used to explain the biological mechanisms linking air pollution and respiratory function, and of arsenic exposure and birth weight. However, mediation analysis of metabolomic markers has not been used to assess air pollution effects on adverse birth outcomes. In this article, we describe the assumptions and applications of mediation analysis using metabolomic markers that elucidate the potential mechanisms of the effects of air pollution on adverse pregnancy and birth outcomes. Summary The hypothesis of mediation along specified pathways can be assessed within the structural causal modeling framework. For causal inferences, several assumptions that go beyond the data—including no uncontrolled confounding—need to be made to justify the effect decomposition. Nevertheless, studies that integrate metabolomic information in causal mediation analysis may greatly improve our understanding of the effects of ambient air pollution on adverse pregnancy and birth outcomes as they allow us to suggest and test hypotheses about underlying biological mechanisms in studies of pregnant women. Keywords Air pollution . Adverse birth outcomes . Metabolomics . Causal mediation analysis . 4-way decomposition
Kosuke Inoue and Qi Yan contributed equally to this work. This article is part of the Topical Collection on Susceptibility Factors in Environmental Health * Beate Ritz [email protected] 1
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. South, Los Angeles, CA 90095, USA
2
Department of Statistics, UCLA College of Letters and Science, Los Angeles, CA, USA
3
Department of Public Health, Aarhus University, Aarhus, Denmark
4
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA
5
Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, Emory University, Atlanta, GA, USA
6
Dep
Data Loading...
