Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway
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Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway Hui‑Hui Sun1 · Xin‑Min Feng1 · Jing‑Cheng Wang1,2 · Jun Cai1,2 Received: 11 May 2020 / Accepted: 19 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Whether allicin can suppress the angiogenesis via inhibiting the activity of vascular endothelial cells (VECs) in preventing epidural hypertrophic scars remains unknown. VECs were treated by allicin at a gradient of concentrations. Cell activity was measured by CCK-8 assay, scratch assay and flow cytometry. Reverse-transcription PCR and Western Blot were used to measure the expression levels of relevant genes and proteins. After treated with allicin at concentrations of 0, 25, 50 and 100 mg/L, the viability of VECs significantly decreased at 24 h (p
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