Amygdalar and hippocampal beta rhythm synchrony during human fear memory retrieval
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ORIGINAL ARTICLE - FUNCTIONAL NEUROSURGERY - EPILEPSY
Amygdalar and hippocampal beta rhythm synchrony during human fear memory retrieval Di Wang 1,2 & Zhaoyang Huang 1,2 & Liankun Ren 1,2 & Jing Liu 3 & Xueyuan Wang 4,5 & Tao Yu 4,5 & Minjing Hu 1,2 & Xueming Wang 1,2 & Jialin Du 1,2 & Duanyu Ni 4,5 & Xi Zhang 4,5 & Runshi Gao 4,5 & Liang Qiao 4,5 & Yuping Wang 1,2,6,7 Received: 18 December 2019 / Accepted: 26 February 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Background Fear, as one of the basic emotions, is crucial in helping humans to perceive hazards and adapt to social activities. Clinically, fear memory is also involved in a wide spectrum of psychiatric disorders. A better understanding of the neural mechanisms of fear thereby has both neuroscientific and clinical significance. In recent years, data from animal models have demonstrated the key role of the amygdala-hippocampal circuit in the development of fear. However, the neural processing of fear memory remains unclear in humans, which is mainly due to the limitation of indirect measure of neural activity. Methods Herein, we investigated fear memory by direct intracranial recordings from 8 intractable epilepsy patients with depth electrodes in both the hippocampus and ipsilateral amygdala. All the patients were subjected to a well-established Pavlovian fear memory paradigm consisted of the familiarization task, conditioning task, and retrieval task, respectively. Simultaneous local field potentials from the hippocampus and amygdala were recorded during different stages. The oscillatory activities from the amygdala and hippocampus were analyzed during fear memory retrieval compared with neutral stages. Results Consistent with previous rodent studies, our results showed that the amygdala was involved in fear memory retrieval rather than neutral memory retrieval, while the hippocampus was involved both in fear memory retrieval and neutral memory retrieval. In particular, we found that there was an enhanced synchronized activity between the amygdala and hippocampus at beta frequencies (14–30 Hz), which suggested that enhanced synchronized activity at beta frequencies between the amygdala and hippocampus play a pivotal role during retrieval of fear memory in human. Conclusions Thus, our observation that the amygdala-hippocampal system contributing to fear memory retrieval in human with frequency-depended specificity has provided new insights into the mechanism of fear and have potential clinical relevance. Keywords Fear memory . Amygdala . Hippocampus . Local field potentials . Epilepsy
This article is part of the Topical Collection on Functional Neurosurgery Epilepsy * Yuping Wang [email protected] 1
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Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Beijing Institute of Functional Neurosurgery, Beijing 100053, China
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The Beijing Key Laboratory of Neuromodula
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