An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics i
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LARYNGOLOGY
An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology‑head and neck surgery clinics in China Shuifang Xiao1 · Jinrang Li2 · Hongliang Zheng3 · Yan Yan4 · Xiangping Li5 · Lihong Zhang6 · Quiping Lv7 · Junbo Zhang1 · Lin Zeng8 · Xia Gao9 · Xiong Chen10,11 · Hui Yang12 · Chen Zhao13 · Jian Zhang14 · Honghua Lu15 · Xianyang Luo16 · Guangke Wang17 · Hongliang Yi18 · Jin Ye19 · Zhenqun Lin20 · Linli Tian21 · Jingjing Zhang22 · Ting Chen23 · Aimin Yu24 · Zhaohui Liu25 · Xiaoyong Ren26 · Xinming Yang27 · Siyi Zhang28 · Xiaobo Cui29 · Gelin Li30 · Guanglun Wan31 · Chang Lin32 · Hui Chen33 · Anchun Deng34 · Xiabing Tang35 · Qingfeng Zhang36,37 · Zhenfeng Tao38 · Li Shi39 · Jianyong Zhou40 · Gang Qin41 · Peiyun Zhuang42 · Hui Huangfu43 · Jianming Yang44 · Guojin Zhou45 · Huijun Li46 · Wei Wu47 · Julan Li48 · Shuhua Li49 · Guangming Lou50 · Hongyan Fang51 · Jiangang Ma52 · Chunguang Shan52 · Xuejun Zhou53 · Liang Tang54 · Fang Zhou55 · Yunping Fan56 · Yanping Zhang57 · Yujie Li58 · Meisheng Li59 · Chunqiang Dou60 · Zhiling Chen61 · Gang Lei62 · Jingbo Li63 · Zhiguang Gao64 · Yongwang Huang65 · Xinchun Ma66 · Zhijun Liu67 · Gengtian Liang68 · Jian He69 · Hua Zhao70 · Bailong Song71 · Meijun Chen72 · Xiangli Yang73 · Zuopeng Ma74 · Jinlong Ren75 Received: 5 April 2020 / Accepted: 9 May 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China. Methods This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13. Results There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P 65 years. According to the smoking and drinking history, patients were assigned to two groups, namely the presence or absence of current smoking or drinking history. Smoking history was defined as ongoing smoking every day (no limit on the number of cigarettes). Drinking history was defined as ongoing drinking every day (no limit on alcohol consumption). For season, spring was March to May, summer was June to August, autumn was September to November, and winter was December to February. The geographical divisions included Northeast China, East China, North China, Central China, South China, Southwest China, and Northwest China.
Statistical analysis Continuous variables were all expressed as means ± standard deviation. The previous LPRD diagnostic rate and the LPRD frequencies in d
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