Analytical Approaches for the Determination and Identification of Drug Metabolites in Plants After Uptake
The present chapter gives an overview of analytical methodologies employed for the identification and quantitation of metabolites formed in plants or plant cell cultures from drugs and personal care products after uptake from water or soil. Important aspe
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ntents 1 Introduction 2 Experimental Approaches for Investigating the Uptake of Drugs by Plants 2.1 Strategies for the Growing of Plants and Their Treatment with Drugs 2.2 Harvesting and Extraction 3 Approaches for Metabolite Detection 4 More Detailed Discussion of Papers Published Within This Field 4.1 Carbamazepine 4.2 Non-steroidal Anti-inflammatory Drugs 4.3 Antibiotics 4.4 Other Drugs for Use in Humans 4.5 Drugs for Veterinary Use Only 4.6 Personal Care Products 5 Conclusions and Perspectives References
Abstract The present chapter gives an overview of analytical methodologies employed for the identification and quantitation of metabolites formed in plants or plant cell cultures from drugs and personal care products after uptake from water or soil. Important aspects like experimental approaches for plant growing, extraction of the investigated analytes from plants, preconcentration strategies, and final analytical techniques allowing the proposal of (at least tentative) structures for drug-related metabolites are discussed. Special emphasis is also set on the elucidation of translocation processes by analyzing different plant parts. In one table, a comprehensive
F. Mlynek, M. Himmelsbach, W. Buchberger, and C. W. Klampfl (*) Institute of Analytical Chemistry, Johannes-Kepler-University Linz, Linz, Austria e-mail: christian.klampfl@jku.at Sandra Pérez Solsona, Nicola Montemurro, Serge Chiron, and Damià Barceló (eds.), Interaction and Fate of Pharmaceuticals in Soil-Crop Systems: The Impact of Reclaimed Wastewater, Hdb Env Chem, DOI 10.1007/698_2020_629, © Springer Nature Switzerland AG 2020
F. Mlynek et al.
overview of the current state of knowledge available from the literature is given, with respect to the topics listed above. Keywords Drug metabolites, Emerging contaminants, Environmental analysis, Environmental metabolomics, Phytouptake
Abbreviations 17α-E2 17β-E2 ALB ATE ATR AVO BHT BMS BPA BZP CAF CBZ CDP CIP CLA CLI CLP CP DCF DP E1 EE2 ENR ESI FAD FAZ FBZ FL FLU FP GEM HPLC HR-MS
17α-Estradiol 17β-Estradiol Albendazole Atenolol Atorvastatin Avobenzone Butylated hydroxytoluene Betamethasone dipropionate Bisphenol A Benzophenone Caffeine Carbamazepine Chlordiazepoxide Ciprofloxacin Clarithromycin Clindamycin Clomipramine Clonazepam Diclofenac Diazepam Estrone Ethinylestradiol Enrofloxacin Electrospray ionization Furaltadone Furazolidone Fenbendazole Fluvastatin Flubendazole Flurazepam Gemfibrozil High-performance liquid chromatography High-resolution mass spectrometry
Analytical Approaches for the Determination and Identification of Drug. . .
IBU IPR KPF LTG MeBT MePB MET MFA NDP NFA NFZ NPX NSAID OBZ OC OFL OP OPL OS PAR PZE QqQ QuEChERS SDM SDZ SER SIM SMR SMT SMX SMZ SPD STZ TA TCP TCS TEL TM TMP TRZ
Ibuprofen Iopromide Ketoprofen Lamotrigine 5-Methyl-1H-benzotriazole Methylparaben Metformin Mefenamic acid Nordiazepam Nitrofurantoin Nitrofurazone Naproxen Non-steroidal anti-inflammatory drug Oxybenzone Octocrylene Ofloxacin Oxazepam 4-Octylphenol Octisalate Paracetamol Phenazone Triple quadrupole Quick,
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