Anemone study: prevalence of risk factors for superficial vein thrombosis in a large Italian population of blood donors
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Anemone study: prevalence of risk factors for superficial vein thrombosis in a large Italian population of blood donors Elvira Grandone1,2 · Giovanni Luca Tiscia1 · Angelo Ostuni3 · Lazzaro di Mauro4 · Mario Mastroianno5 · Nadia Coffetti6 · Roberto Dovigo6 · Giovanna Meneghini7 · Anna Turrini8 · Giobatta Cavallero9 · Filomena Cappucci1 · Patrizia Vergura1 · Antonio De Laurenzo1 · Alberto Tosetto10 · Maurizio Margaglione11 on behalf of FCSA (Italian Federation of Anticoagulation Clinics)
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Knowledge of the distribution of risk factors for superficial thrombosis (SVT) in low-risk population is fundamental to improve the prevention of the disease in each individual and high-risk settings of patients. Exact frequency data for the lowrisk population are scarce, but could be useful for optimal use of prophylactic strategies against venous thrombosis. Blood donors represent a low-risk population, because are healthier than the general population. The objective of this study was to assess the prevalence of vein thrombosis, particularly SVT, and associated risk factors in a low-risk population such as blood donors. In this multicentre cross-sectional study, donors from six Italian blood banks responded to a self-administered questionnaire. The enrolment lasted from 1st June 2017 to 30th July 2018. History of vein thrombosis was referred by 89 (0.76%) individuals, (49 men) with an age-dependent effect. The prevalence reached 2.9% in women and 0.8% in men aged ≥ 49 years, with a significant difference only for women. After controlling for potential confounders, a significant and independent association was found between a history of vein thrombosis and age (OR: 1.03, 95%CI 1.01–1.05), varicose veins (OR: 15.8, 95%CI 7.7–32.6), plaster cast/bed rest (OR: 2.3, 95% CI 1.0–5.3) and transfusion (OR: 5.1, 95% CI 1.3–19.5). This study shows that low-risk individuals share the same risk factors for SVT as patients in secondary care. It also suggests that transfusion confers an increased risk of SVT in healthy population. Keywords Superficial vein thrombosis · Blood donors · Risk factors · Anticoagulation Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11239-020-02140-5) contains supplementary material, which is available to authorized users. * Elvira Grandone [email protected] 1
Thrombosis and Haemostasis Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy
2
Ob/Gyn Department of The First I.M. Sechenov Moscow State Medical University, Moscow, Russia
3
Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari “Aldo Moro”, and Struttura Regionale Coordinamento Puglia, Bari, Italy
4
Immunohematology and Transfusion Medicine Service, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy
5
Scientific Direction, Fondazione IRCCS “Casa Sollievo dell
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