Annual Update in Intensive Care and Emergency Medicine 2012
The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is add
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2012
Annual Update in Intensive Care and Emergency Medicine 2012 Edited by J.-L. Vincent
The series Annual Update in Intensive Care and Emergency Medicine is the continuation of the series entitled Yearbook of Intensive Care Medicine in Europe and Intensive Care Medicine: Annual Update in the United States. Editor: Prof. Jean-Louis Vincent Head, Department of Intensive Care Erasme Hospital, Universit´e libre de Bruxelles Route de Lennik 808, B-1070 Brussels, Belgium
ISBN 978-3-642-25715-5
ISBN 978-3-642-25716-2 (eBook)
DOI 10.1007/978-3-642-25716-2 ISSN 2191-5709 Springer Heidelberg Dordrecht London New York ˇ Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover Design: WMXDesign GmbH, Heidelberg Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
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Table of Contents
I Mechanisms of Sepsis and Critical Illness Molecular Mechanisms Underlying Severe Sepsis: Insights from Epigenetics W.F. Carson IV and S.L. Kunkel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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The Neuroendocrine Axis: The Nervous System and Inflammation K. Weismüller, M.A. Weigand, and S. Hofer . . . . . . . . . . . . . . . . . . . . . . . 12 The mHLA-DR System in the Critically Ill A. Gouel, A. Lepape, and B. Allaouchiche . . . . . . . . . . . . . . . . . . . . . . . . 19 Gut Microbiome and Host-defense Interactions during Critical Illness T.J. Schuijt, T. van der Poll, and W.J. Wiersinga . . . . . . . . . . . . . . . . . . 29
II Metabolomics The Metabolomic Approach to the Diagnosis of Critical Illness N. Nin, J.L. Izquierdo-Garc´ıa, and J.A. Lorente . . . . . . . . . . . . . . . . . . . . 43 Metabolomics in Critically ill Patients: Focus on Exhaled Air L.D.J. Bos, P.J. Sterk, and M.J. Schultz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
III Sepsis Management Cardiovascular Effects of Norepinephrine in Septic Shock X. Monnet and J.-L. Teboul . . .
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