Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island
- PDF / 1,377,198 Bytes
- 8 Pages / 609 x 794 pts Page_size
- 84 Downloads / 160 Views
pISSN 1226-8372 eISSN 1976-3816
RESEARCH PAPER
Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island Seul Ki Min, Jung Eun Kim, Ju-Mi Hong, Joung Han Yim, Hyun Park, Ui Joung Youn, Se Jong Han, and Il-Chan Kim
Received: 1 October 2019 / Revised: 16 January 2020 / Accepted: 17 February 2020 © The Korean Society for Biotechnology and Bioengineering and Springer 2020
Abstract Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopolysaccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1β and 1α (IL-6, IL-1β and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs. Keywords: Lecania gerlachei, lichens, Antarctica, antiinflammatory properties, nuclear factor kappa B (NF-κB) pathway Seul Ki Min, Jung Eun Kim, Ju-Mi Hong, Joung Han Yim, Ui Joung Youn, Se Jong Han, Il-Chan Kim* Division of Polar Life Science, Korea Polar Research Institute, Incheon 21990, Korea Tel: +82-32-760-5500; Fax: +82-32-760-5509 E-mail: [email protected] Jung Eun Kim School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea Hyun Park Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea
1. Introduction Inflammation is part of the host defense response to infection and is regulated by various mediators, including cytokines and chemokines released from immune cells such as macrophages [1]. Typical signs of inflammation are redness, heat, pain, and swelling induced by pro-inflammatory factors such as interleukin 6 (IL-6), IL-10, and tumor necrosis factor α (TNF-α) and immune mediators such as nitric oxide (NO) and Prostaglandin E2 (PGE2) [1]. Chronic inflammation is a causal factor closely linked to various diseases including cancer, cardiovascular as well as disease arthritis and diabetes [2], and many drugs have been developed for the treatment of these inflammation-related diseases. Steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in pain relief management from disease-induced inflammatory reactions. However, as these drugs exhibit a number of side effects, many researchers have focused towards the development of alternative drugs [3]. In recent years,
Data Loading...
