Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Toleran
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ARTICLE
Cite as Nano-Micro Lett. (2019) 11:93 Received: 9 August 2019 Accepted: 14 October 2019 © The Author(s) 2019
https://doi.org/10.1007/s40820-019-0327-4
Antiangiogenesis‑Combined Photothermal Therapy in the Second Near‑Infrared Window at Laser Powers Below the Skin Tolerance Threshold Jian‑Li Chen1, Han Zhang2, Xue‑Qin Huang1, Hong‑Ye Wan1, Jie Li1, Xing‑Xing Fan1, Kathy Qian Luo3, Jinhua Wang4, Xiao‑Ming Zhu1 *, Jianfang Wang2 * * Xiao‑Ming Zhu, [email protected]; Jianfang Wang, [email protected] State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China 2 Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People’s Republic of China 1
3 4
Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People’s Republic of China Beijing Key Laboratory of Drug Targets Research and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China
HIGHLIGHTS • Titania-coated Au nanobipyramids (NBP@TiO2) with a high photothermal conversion efficiency in the NIR-II window are synthesized. • The TiO2 shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P). • The CA4P-loaded NBP@TiO2 nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value.
ABSTRACT Photothermal agents with strong light absorption in the
1064 nm
second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired
Photothermal therapy
Antiangiogenesis
for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO2) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO2 nanostructures
have a high photothermal conversion efficiency of (93.3 ± 5.2)% under
NBP@TiO2 CA4P
1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer
CA4P-NBP@TiO2
A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a
synergistic antiangiogenesis effect. In vivo studies show that such CA4P-
loaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm−2, which is lower than the skin
tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy. KEYWORDS Antiangiogenesis therapy; Core@shell nanostructures; Gold nanobipyramids;
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