Antibiotic use in children with Kawasaki disease
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LETTER TO THE EDITOR
Antibiotic use in children with Kawasaki disease Seung Beom Han1 · Soo‑Young Lee1,2 Received: 29 December 2017 / Accepted: 18 April 2018 © Children’s Hospital, Zhejiang University School of Medicine 2018
As the diagnostic criteria for Kawasaki disease (KD) consist of the clinical features that are shared by other childhood febrile illnesses [1, 2], KD is sometimes confused with a bacterial infection, leading to clinical situations in which children with the disease receive antibiotics [3–5]. Here, we report the extent of antibiotic use in children with KD and the clinical parameters confusing KD with a bacterial infection. In this retrospective study, medical records for 140 children (86 boys) who were diagnosed with KD at a university hospital in Seoul, between January 2015 and December 2016, were reviewed. Diagnosis of KD was based on American Heart Association criteria [2]. All children with KD received treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose) and underwent echocardiography during hospitalization. Of the children with KD, 54.3% (76/140) received treatment with intravenous antibiotics (ampicillin/sulbactam or cefotaxime 100–200 mg/kg/day) before the diagnosis of KD was assigned. Table 1 summarizes comparisons of the clinical and laboratory findings between the KD with antibiotics group (n = 76) and the KD without antibiotics group (n = 64). The KD with antibiotics group was younger (P
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