Antiviral Activity of Silver Nanoparticles Immobilized onto Textile Fabrics Synthesized by Radiochemical Process
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Antiviral Activity of Silver Nanoparticles Immobilized onto Textile Fabrics Synthesized by Radiochemical Process Satoshi Seino1, Yasuo Imoto1&2, Tomoya Kosaka1, Tomoki Nishida2, Takashi Nakagawa1 and Takao A. Yamamoto1 1 Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. 2 Japan Textile Products Quality and Technology Center, 5-7-3, Shimoyamate-dori, Chuo-ku, Kobe-city, Hyogo, 650-0011, Japan. ABSTRACT Antiviral activity of metallic Ag nanoparticles immobilized on textile fabrics were investigated. The Ag nanoparticles synthesized by radiochemical process are firmly immobilized on the surface of support textile fabrics of cotton. Small Ag particles of about 2–4 nm were observed together with relatively large particles of more than 10 nm. The Ag nanoparticles showed antiviral activity against Influenza A and Feline Calicivirus. The antiviral activity significantly depended on the concentration of the Eagle’s minimal essential medium. It was implied that the surface passivation by inhibitory agent lead to the deactivation of metallic Ag nanoparticles. INTRODUCTION As the pathogenic viruses are always major threat to the human society, various kinds of antiviral agents are widely studied by many researchers. Of the various kinds of antiviral agent available, silver nanoparticles have received significant attention [1-3]. Although inhibition mechanism of silver nanoparticle is not only an academically important research subject but also an essential information for their practical applications, it is not thoroughly understood yet. With conventional studies, colloidal silver nanoparticles were usually used because they are easily synthesized in aqueous solution systems and applied for antiviral test systems. However, usual colloidal silver nanoparticles are coated with surfactants or polymers control their size and stability in solution system, which make difficult to discuss their surface effect against viruses. Also, effect of free silver nanoparticles on virus-infected cells, which are used for quantitative analysis of virus activity, sometimes make difficult to discuss the antiviral effect only. In recent years, our research group developed a new technique for synthesizing silver nanoparticles immobilized on textile fabrics using a radiochemical process [4]. We have already reported that the metallic silver nanoparticles on textile fabrics show excellent antibacterial activities. Also, the Ag modified textile fabrics showed high durability against washing process. In this paper, antiviral activities of silver nanoparticles with bared surfaces were investigated. As the silver nanoparticles are firmly immobilized on support textile fabrics and their effects on virus-infected cells are negligible. Also, as no surfactants or polymers are applied in the synthesis process, the silver nanoparticles on textile fabrics have bared surface, which would interact with viruses directly.
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EXPERIMENTS Detailed procedure for the radiochemical synthesis is described elsewhere [4]. Tex
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