Application of clay as a means of support to biomaterial with anti-inflammatory agents
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Application of clay as a means of support to biomaterial with anti-inflammatory agents M.L.Domínguez-Patiño1,*, M.Chávez-Castillo2, A. Rodríguez-Martínez3, R.M. Melgoza Alemán1, E.Jiménez-Ferrer4, M. Herrera-Ruíz4 1
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209,Cuernavaca, Morelos, México. E-mail: [email protected] 2
Posgrado en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209,Cuernavaca, Morelos, México. E-mail: [email protected] 3
Centro de Investigación en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, México. 4
Centro de Investigación Biomédica del Sur (IMSS), Argentina No. 1, Col. Centro Xochitepec, Morelos 62790, México.
ABSTRACT In the last fifteen years, there have been significant changes in the production of medicines, mainly in the addition of new components to the formulation of solid dosage forms. The current trend of "back to nature" to lead to a healthier life has led those who are engaged in the pharmaceutical field to develop new formulations that allow the use of natural products of plant origin. For example, excipient ingredients, used as carriers for a drug’s active ingredients, are now being used. These are incorporated into a drug in order to facilitate the drug’s preparation, maintenance, or administration. The excipient is beneficial to the patient because it allows the drug to be easily administered and absorbed by the human body [3]. There is evidence that the clays have great potential for both absorption and adsorption due to its tiny particles. In addition, it has been reported that some clays have an effective antiseptic and healing ability [5-8]. In the present work, a clay called bentonite was tested as a support vehicle of an inflammatory agent derived from a Mexican native plant called Distictis buccinatoria, commonly named "Tonacaxóchitl". Studies carried out by Rojas et al. have shown that the organic extract of this plant has important antibacterial, antifungal, cytotoxic and anti-inflammatory properties [9].
INTRODUCTION Increased life expectancy of human beings in developed countries has meant that contemporary science is increasingly devoted to the solution of pathologies or trauma associated with low mortality but high morbidity, which have a significant impact on aesthetics, functional capacity and quality of life of the individual [4]. The logical tendency to prevent the gradual decline in ability is a challenge for human intelligence, which has resulted in a growing importance of the science and medical device industry to address the problem of incorporating "non-living" material into the body, which interact in one way or another with the biological medium. From a market perspective, the emergence and consolidation of new, sophisticated and safe surgical techniques, together with the factors already mentioned, has led to a growing demand for dentures, implants, and medical devices and systems.
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