Applied Bioinformatics An Introduction
Confused by cryptic computer programs, algorithms and formulae? In this book, anyone who can operate a PC, standard software and the Internet will learn to understand the biological basis of bioinformatics of the existence as well as the source and availa
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P.M. Selzer • R.J. Marhöfer • A. Rohwer
Applied Bioinformatics An Introduction
With 69 Figures, 61 in color and 6 Tables
Prof. Paul M. Selzer, Ph.D. Intervet Innovation GmbH BioChemInformatics Zur Propstei 55270 Schwabenheim Germany [email protected]
Andreas Rohwer, Ph.D. Intervet Innovation GmbH BioChemInformatics Zur Propstei 55270 Schwabenheim Germany [email protected]
Richard J. Marhöfer, Ph.D. Intervet Innovation GmbH BioChemInformatics Zur Propstei 55270 Schwabenheim Germany [email protected] Translators: PD Frank Seeber, Ph.D. Dept. Biology/Parasitology Philipps University Marburg Karl-von-Frisch-Str. 8 35042 Marburg Germany [email protected]
Conor Caffrey, Ph.D. Director of Biochemistry and Molecular Parasitology Sandler Center for Basic Research in Parasitic Diseases Byers Hall N508 University of California, San Francisco 1700 4th Street San Francisco, CA 94158-2330 USA [email protected]
ISBN: 978-3-540-72799-6
e-ISBN: 978-3-540-72800-9
Library of Congress Control Number: 2007937094 © 2008 Springer-Verlag Berlin Heidelberg First published in German under the title: Angewandte Bioinformatik 2004 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg, Germany Printed on acid-free paper springer.com
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Preface
Though a relatively young discipline, bioinformatics is finding increasing importance in many life science disciplines, including biology, biochemistry, medicine, and chemistry. Since its beginnings in the late 1980s, the success of bioinformatics has been associated with rapid developments in computer science, not least in the relevant hardware and software. In addition, biotechnological advances such as those witnessed in the fields of genome sequencing, microarrays and proteomics have contributed enormously to the bioinformatics boom. Finally, the simultaneous breakthrough and success of the World-Wide Web has facilitated the worldwide distribution of and easy access to bioinformatics tools. Today, bioinformatics techniques such as the BLAST algorithm, pairwise and multiple sequence comparisons, queries of biological databases, and phylogenetic analyses have become familiar tools to the natural scientist. Many of the
