Assessment of eldecalcitol and alendronate effect on postural balance control in aged women with osteoporosis
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ORIGINAL ARTICLE
Assessment of eldecalcitol and alendronate effect on postural balance control in aged women with osteoporosis Takao Suzuki1 · Atsushi Harada2 · Hiroyuki Shimada3 · Takayuki Hosoi4 · Yuichi Kawata5 · Tomoyuki Inoue6 · Hitoshi Saito5 Received: 23 December 2019 / Accepted: 7 June 2020 © The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020
Abstract Introduction Older people aged over 75 are more prone to falls because physical functions become deteriorated along with aging, and also fracture risk is strongly correlated with age. We evaluated the effects of anti-osteoporosis agents, eldecalcitol (ELD) and alendronate (ALN) on physical functions by assessing dynamic and static postural balance in aged patients with osteoporosis. Materials and methods A randomized, open-label, controlled clinical trial has been conducted with 124 female patients aged 65 or over with osteoporosis. Patients were randomly assigned to receive either 0.75 μg of ELD once-a-day or 35 mg of ALN once-a-week for 24 weeks. The primary endpoint was the change in a postural balance index, adjusted composite equilibrium score (CES) of sensory organization test (SOT). The SOT equilibrium scores, leg muscle strength, and other physical functions were also evaluated. Results The Adjusted CES increased from baseline by 6.10% in the ELD group and 6.28% in the ALN group. There was no statistically significant difference between the two groups. The static postural balance at fixed platform were maintained in the ELD group, but declined in the ALN group. The dynamic postural balance at swaying platform and knee extension power increased from baseline in both groups. Conclusions These results suggest that ELD and ALN treatments may each be beneficial to improve postural balance control in older patients with osteoporosis via different mechanisms of action. Keywords Osteoporosis · Bisphosphonate · Vitamin D · Postural balance · Muscle strength
Introduction Osteoporotic fractures often occur in aged individuals aged 75 years or older [1], and it is also well-recognized that fracture risk is strongly correlated with age. Older individuals * Takao Suzuki [email protected] 1
Institute of Gerontology, J. F. Oberlin University, 3758 Tokiwa‑machi, Machida 194‑0294, Tokyo, Japan
2
Department of Orthopedic Surgery, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
3
Department of Preventive Gerontology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
4
Kenkoin Clinic, Tokyo, Japan
5
Chugai Pharmaceutical Co. Ltd., Tokyo, Japan
6
Taisho Pharmaceutical Co. Ltd., Tokyo, Japan
are more prone to falls than are younger adults, and major non-vertebral osteoporotic fractures (hip, distal radial, and humeral fractures) are mainly caused by falls. Age-related risk factors of falls include muscle weakness, slower muscle reaction time, balance deterioration, slower gait speed, visual deficits, and cognitive impairment [2]. These factors are part of the na
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