Assessment of left and right ventricular functional parameters using dynamic dual-tracer [ 13 N]NH3 and [ 18 F]FDG PET/M
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Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria Division of Cardiovascular and Interventional Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria QIMP Team, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria Artificial Intelligence in Medicine Program, Cedars-Sinai Medical Center, Los Angeles, California Clinical Division of General Surgery, Medical University of Vienna, Vienna, Austria Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria
Received May 5, 2020; accepted Sep 16, 2020 doi:10.1007/s12350-020-02391-y
Background. Cardiac positron emission tomography/magnetic resonance imaging (PET/ MRI) can assess various cardiovascular diseases. In this study, we intra-individually compared right (RV) and left ventricular (LV) parameters obtained from dual-tracer PET/MRI scan. Methods. In 22 patients with coronary heart disease (69 ± 9 years) dynamic [13N]NH3 (NH3) and [18F]FDG (FDG) PET scans were acquired. The first 2 minutes were used to calculate LV and RV first-pass ejection fraction (FPEF). Additionally, LV end-systolic (LVESV) and enddiastolic (LVEDV) volume and ejection fraction (LVEF) were calculated from the early (EP) and late-myocardial phases (LP). MRI served as a reference. Results. RVFPEF and LVFPEF from FDG and NH3 as well as RVEF and LVEF from MRI were (28 ± 11%, 32 ± 15%), (32 ± 11%, 41 ± 14%) and (42 ± 16%, 45 ± 19%), respectively. LVESV, LVEDV and LVEF from EP FDG and NH3 in 8 and 16 gates were [71 (15 to 213 mL), 98 (16 to 241 mL), 32 ± 17%] and [50 (17 to 206 mL), 93 (13 to 219 mL), 36 ± 17%] as well as [60 (19 to 360 mL), 109 (56 to 384 mL), 41 ± 22%] and [54 (16 to 371 mL), 116 (57 to 431 mL), 46 ± 24%], respectively. Moreover, LVESV, LVEDV and LVEF acquired from LP FDG and NH3 were (85 ± 63 mL, 138 ± 63 mL, 47 ± 19%) and (79 ± 56 mL, 137 ± 63 mL, 47 ± 20%), respectively. The LVESV, LVEDV from MRI were 93 ± 66 mL and 153 ± 71 mL, respectively. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12350-020-02391-y) contains supplementary material, which is available to authorized users. This article includes a PowerPoint file that should be made available as ESM on SpringerLink. Please include the standard Springer ESM text in the note/footer on the first article page. Below this, include the following text: ‘‘The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarizes the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com.
The authors have also provided an audio summary of the article, which is available to download as ESM, or to listen to via the JNC/ASNC Podcast. Funding The study was partly funded by Siemens Healthineers, Erlangen, Germany. Reprint requests: Marcus Hacker, MD, Division of Nuclear Medi
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