Assessment of SE-MRE-derived shear stiffness at 3.0 Tesla for solid liver tumors characterization
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HEPATOBILIARY
Assessment of SE‑MRE‑derived shear stiffness at 3.0 Tesla for solid liver tumors characterization Andrés Dominguez1,2 · Daniel Fino1,2,3 · Juan Carlos Spina4 · Nicolas Moyano Brandi1,2,5 · Joaquín Capó1,2,5 · Maximiliano Noceti1,2 · Pedro Pablo Ariza1,2 · Guilherme Moura Cunha6 Received: 21 August 2020 / Revised: 7 October 2020 / Accepted: 10 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Objectives To evaluate the feasibility and diagnostic value of using a 2D spin-echo MR elastography (SE-MRE) sequence at 3.0 Tesla for solid focal liver lesions (FLL) characterization. Methods This prospective study included 55 patients with solid FLL (size > 20 mm), who underwent liver SE-MRE at 3 Tesla between 2016 and 2019. Stiffness measurements were performed by two independent readers blinded to the complete MRI exam or patient information. Histological confirmation or typical behavior on the complete MRI exam evaluated in consensus by expert abdominal radiologists was used as reference standard. FLLs were grouped and compared (malignant vs. benign) using the Mann–Whitney and Kruskal–Wallis tests. MRE diagnostic performance was assessed, and stiffness cutoffs were obtained by analysis of ROC curves from accuracy maximization. A linear regression plot was used to evaluate inter-rater agreement for FLLs stiffness measurements. p values 0.05). Median stiffness values of each FLL subgroup are shown in Table 1. When comparing the two groups, malignant lesions had significantly higher stiffness values than the benign group (p
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