Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional s
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RESEARCH ARTICLE
Open Access
Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross‑sectional study Shinya Furukawa1* , Sen Yagi2, Kana Shiraishi3, Kenichirou Mori4, Tomoyuki Ninomiya4, Keitarou Kawasaki5, Yuji Mizukami6, Seiyuu Suzuki7, Masayoshi Uraoka8, Naozumi Shibata9, Sanae Nakamura10, Satoshi Imamine11, Hidehiro Murakami2, Katsuhisa Ohashi12, Masamoto Torisu13, Aki Hasebe14, Harumi Yano15, Masato Murakami16, Eiji Takeshita17, Yoshio Ikeda18 and Yoichi Hiasa3
Abstract Background: Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. Methods: The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0–1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and antiTumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. Results: The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19–0.810], very high: OR 0.37 [95%CI 0.17–0.77], p for trend = 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18–0.73], high: OR 0.41 [95% CI 0.19–0.83], and very high: OR 0.45 [95% CI 0.21–0.94], p for trend = 0.033) after adjustment for confounding factors. Conclusions: Among patients with UC, platelet count was independently inversely associated with MH Keywords: Platelet, Mucosal healing, Ulcerative colitis Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by a disease course involving relapses and remissions [1]. Mucosal healing (MH) is inversely associated with clinical relapse, rates of hospitalization and surgery, and incidence of colorectal cancer *Correspondence: [email protected] 1 Health Services Center, Ehime University, Bunkyo,Matsuyama, Ehime 790‑8577, Japan Full list of author information is available at the end of the article
[2–7]. Thus, MH has been indicated as the therapeutic goal for UC. Endoscopy is considered the gold standard for evaluating MH, but frequent endoscopic procedures are invasive, inconvenient, expensive, and occasionally cause complications. Platelet count is considered to be an inflammation marker. Platelet count among active UC patients was higher t
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