Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study
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NEURO-EPIDEMIOLOGY
Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study Marzieh Araghi1 · Martin J. Shipley1 · Ian B. Wilkinson2 · Carmel M. McEniery2 · Carlos A. Valencia‑Hernández1 · Mika Kivimaki1 · Séverine Sabia1,3 · Archana Singh‑Manoux1,3 · Eric J. Brunner1 Received: 23 August 2019 / Accepted: 13 November 2019 © The Author(s) 2019
Abstract Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness and cognitive decline in a large prospective cohort study with three repeated cognitive assessment over 7 years of follow-up. Aortic pulse wave velocity (PWV) was measured among 4300 participants (mean ± standard deviation age 65.1 ± 5.2 years) in 2007–2009 and categorized based on the tertiles: (lowest third: 8.91 m/s). A global cognitive score was calculated in 2007–2009, 2012–2013, and 2015–2016 based on responses to memory, reasoning and fluency tests. Standardized global cognitive score (mean = 0, SD = 1) in highest third versus lowest third of PWV category was lower at baseline (− 0.12, 95% CI − 0.18, − 0.06). Accelerated 7-year cognitive decline was observed among individuals with the highest PWV [difference in 7-year cognitive change for highest third versus lowest third PWV: − 0.06, 95% CI − 0.11, − 0.01, P
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