Autoimmune Diseases of the Skin Pathogenesis, Diagnosis, Management
Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorde
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Michael Hertl (ed.)
Autoimmune Diseases of the Skin Pathogenesis, Diagnosis, Management Third, Revised and Enlarged Edition
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Editor Michael Hertl, MD Professor and Chairman Department of Dermatology and Allergology, Philipps University, Marburg, Germany
Front Cover: Systemic lupus erythematosus (A) with subepidermal cytoid bodies and positive lupus band test in lesional skin (B), subacute lupus erythematosus (C) and livedo vasculopathy (D). Printed with financial support of Biotest AG Dreieich, Germany This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product liability: The publisher can give no guarantee for all the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. © 2001, 2005 and 2011 Springer-Verlag/Wien Printed in Austria SpringerWienNewYork is a part of Springer Science+Business Media springer.at The publisher and editor kindly wish to inform you that in some cases, despite their best efforts to do so, the obtaining of copyright permissions and usage of excerpts of text is not always successful. © Illustrations: all illustrations with courtesy of the authors Cover Design: WMXDesign GmbH, Heidelberg, Germany Typesetting: le-tex publishing services GmbH, Leipzig, Germany Printing and binding: Theiss GmbH, St. Stefan, Austria Printed on acid-free and chlorine-free bleached paper
SPIN: 12550098 Library of Congress Control Number: 2010932332 With 95 colored figures
ISBN 978-3-211-99224-1 SpringerWienNewYork ISBN 978-3-211-20686-8 2nd edition SpringerWienNewYork
Foreword
Based on recent advances in the understanding of the immunological pathogenesis of many chronic inflammatory disorders there is increasing evidence that several of them are characterized and potentially mediated by autoimmune phenomena. Classical examples are rheumatoid arthritis, myasthenia gravis, pemphigus vulgaris, lupus erythematosus and multiple sclerosis. Others, such as psoriasis vulgaris, some less well-characterized collagen vascular disorders, vasculitides and a subtype of chronic urticaria have a more or less pronounced autoimmune background that has to be considered in the overall management of these disorders. A significant portion of autoimmune diseases precipitate primarily or secondarily at the skin. Understanding the cutaneous symptoms may be therefore crucial for the diagnosis, classification and therapeutic management of organ-specific and systemic disorde
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