Baerveldt glaucoma drainage implant surgery for secondary glaucoma in patients with transthyretin-related familial amylo
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CLINICAL INVESTIGATION
Baerveldt glaucoma drainage implant surgery for secondary glaucoma in patients with transthyretin‑related familial amyloid polyneuropathy Shinji Kakihara1 · Takao Hirano1 · Akira Imai1 · Teruyoshi Miyahara1 · Toshinori Murata1 Received: 15 November 2019 / Accepted: 14 May 2020 © Japanese Ophthalmological Society 2020
Abstract Purpose To investigate outcomes associated with Baerveldt glaucoma drainage implant (BGI) surgery for refractory glaucoma secondary to transthyretin (TTR)-related familial amyloid polyneuropathy (FAP) with TTR Val30Met mutation. Study design Retrospective case series. Methods Medical records of 5 eyes of 4 patients were reviewed. All patients had refractory glaucoma secondary to FAP with a history of unsuccessful intraocular pressure (IOP) control by trabeculectomy with mitomycin C, underwent BGI surgery, and were followed up for at least 1 year. The primary outcome was mean postoperative IOP, and secondary outcomes included the number of ocular hypotensive medications and postoperative complications. Results The mean postoperative follow-up period was 52.4 months. The mean preoperative IOP of 37.0 mmHg was reduced to 13.4 mmHg immediately postoperatively, and respective subsequent means were 15.8, 13.0, 14.4, and 16.8 mmHg at 1, 3, 6, 12, and 24 months (P
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