Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders
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GENETICS (AP MORRIS, SECTION EDITOR)
Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders Niels Vos 1 & Sabrina M. Oussaada 2 & Mellody I. Cooiman 3 & Lotte Kleinendorst 1 & Kasper W. ter Horst 2 & Eric J. Hazebroek 3 & Johannes A. Romijn 4 & Mireille J. Serlie 2 & Marcel M. A. M. Mannens 5 & Mieke M. van Haelst 1,6
# The Author(s) 2020
Abstract Purpose of Review The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a confirmed genetic defect (genetic obesity disorders). Therefore, this review aims to elucidate the role of bariatric surgery in the treatment of genetic obesity. Recent Findings In monogenic non-syndromic obesity, an underlying genetic defect seems to be the most important factor determining the efficacy of bariatric surgery. In syndromic obesity, bariatric surgery result data are scarce, and even though some promising follow-up results have been reported, caution is required as patients with more severe behavioral and developmental disorders might have poorer outcomes. Summary There is limited evidence in support of bariatric surgery as a treatment option for genetic obesity disorders; hence, no strong statements can be made regarding the efficacy and safety of these procedures for these patients. However, considering that patients with genetic obesity often present with life-threatening obesity-related comorbidities, we believe that bariatric surgery could be considered a last-resort treatment option in selected patients. Keywords Obesity . Genetics . MC4R . Bariatric surgery . PWS
Introduction Obesity is one of the leading health problems globally. According to the World Health Organization (WHO), the
global number of patients suffering from obesity has almost tripled over the past 45 years, resulting in an increased prevalence of obesity-associated comorbidities, including cardiovascular diseases and diabetes. These comorbidities are the
Sabrina M. Oussaada and Mellody I. Cooiman contributed equally to this work. This article is part of the Topical Collection on Genetics Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11892-020-01327-7) contains supplementary material, which is available to authorized users. * Mieke M. van Haelst [email protected]
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Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
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Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam Reproduction and Development Research Institute, Meibergdreef 9, Amsterdam, The Netherlands
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Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
Genome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterd
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