Biochemical and Molecular Mechanisms after Severe Traumatic Brain Injury in Children
Secondary damage after severe traumatic brain injury (TBI) in infants and children represents the key target for the development and application of novel therapies. Our group at the Safar Center for Resuscitation Research and the Children’s Hospital of Pi
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2002
Springer- Verlag Berlin Heidelberg GmbH
Yearbook of Intensive Care and Emergency Medicine 2002 Edited by J.-L. Vincent
With 170 Figures and 101 Tables
,
Springer
Prof. jean-Louis Vincent Head, Department of Intensive Care Erasme Hospital, Free University of Brussels Route de Lennik 808, B-1070 Brussels, Belgium
ISBN 978-3-540-43149-7 ISBN 978-3-642-56011-8 (eBook) DOI 10.1007/978-3-642-56011-8 ISSN 0942-5381 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specificaIly the rights of translation, reprinting, reuse of iIlustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are Iiable for prosecution under the German Copyright Law. http://www.springer.de © Springer-Verlag Berlin Heidelberg 2002
Originally published by Springer-Verlag Berlin Heidelberg New York in 2002
The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Iiability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant Iiterature. Typesetting: K + V Fotosatz, Beerfelden
SPIN: 10904008
21/31 II - 54321 - Prioted 00 acid-free paper
Contents
Cellular Responses Ischemia-reperfusion and Acute Apoptotic Cell Death (BS Abella and LB Becker)
3
Alpha-4 Integrin: A Novel Mechanism for Neutrophil-endothelial Interaction. . . (V Gill, P Kubes, and Cf Doig) Cell Adhesion Molecules and Leukocyte Trafficking in Sepsis. (Sf Finney, TW Evans, and A Burke-Gaffney) Molecular Mechanisms of Complement Activation during Ischemia and Reperfusion . . . . . . . . . . . (CLF Ciurana and CE Hack)
12 23
. . . ... . .39. .
Gender and Cell-mediated Immunity following Trauma, Shock, and Sepsis . . . . . . . . .... . ..... . . . . . . .50. . . . (MG Schwacha, A Samy, and IH Chaudry)
. . .
Basic Mechanisms in Acute Respiratory Failure Regulatory Role of Alveolar Macrophages and Cytokines in Pulmonary Host Defense . . . . . . . . . . . . . . . . . . .... . . 65 . (Mf Schultz, S Knapp, and T van der Poll) Apoptosis in Pneumonia . . . . . . . . . . . . . . . (B Guery, fF Pittet, and P Marchetti)
. . . .. . . . 77 ....
Hypoxic Pulmonary Vasoconstriction and the Pulmonary Microcirculation. . . . . . . . . . . . . . . .. . (DL Traber and LD Traber)
93.
Pulmonary Endothelial Angiotensin Converting Enzyme Activity in Lung Injury . . . . . . . . . . . . . . . . . . . . . .100 ..... (SE Orfanos, A Kotan
