Biomechanical signal communication in vascular smooth muscle cells
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REVIEW
Biomechanical signal communication in vascular smooth muscle cells Jingbo Chen 1 & Yan Zhou 1 & Shuying Liu 1 & Chaohong Li 1 Received: 13 February 2020 / Accepted: 4 August 2020 # The International CCN Society 2020
Abstract Biomechanical stresses are closely associated with cardiovascular development and diseases. In vivo, vascular smooth muscle cells are constantly stimulated by biomechanical factors caused by increased blood pressure leading to the non-specific activation of cell transmembrane proteins. Thus, various intracellular signal molecules are simultaneously activated via signaling cascades, which are closely related to alterations in the differentiation, phenotype, inflammation, migration, pyroptosis, calcification, proliferation, and apoptosis of vascular smooth muscle cells. Meanwhile, mechanical stress-induced miRNAs and epigenetics modification on vascular smooth muscle cells play critical roles as well. Eventually, the overall pathophysiology of the cells is altered, resulting in the development of many major clinical diseases, including hypertension, atherosclerosis, grafted venous atherosclerosis, and aneurysm, among others. In this paper, important advances in mechanical signal communication in vascular smooth muscle cells are reviewed. Keywords Mechanical stress . Mechanoreceptors, Vascular smooth muscle cells . Signal transduction . MicroRNA . Epigenetics
Abbreviations ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 AIM2 Absent in melanoma 2 AC Adenylate cyclase AT1R Angiotensin II type 1 receptor AR Adrenergic receptor AGEs Advanced glycation end products CS Cyclic strain ECs Endothelial cells eNOS Endothelial nitric oxide synthase ERKs Extracellular receptor kinases FAK Focal adhesion kinase Jingbo Chen and Yan Zhou contributed equally to this work. * Shuying Liu [email protected] * Chaohong Li [email protected] Jingbo Chen [email protected] Yan Zhou [email protected] 1
Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
GPCRs IRS-1 IGF-1R IFN-γ IL-6 JNKs LOX-1 MCP-1 MKP-1 MMP MSCs MiRNAs MAPK NOX1 NSCC OX-LDL PUMA PI3K PLC PDGFRs PDI PKA PKC RhoA ROS RAGE
G protein-coupled receptors Insulin receptor substrate-1 Insulin-like growth factor 1 receptor Interferon-γ Interleukin-6 C-Jun N-terminal kinases Lectin-like oxidized low-density lipoprotein receptor-1 Monocyte chemoattractant protein-1 MAPK phosphatase-1 Matrix metalloproteinase Mesenchymal stem cells MicroRNAs Mitogen-activated protein kinase NADPH oxidase subunits 1 Non-selective cation channel current Oxidized low-density lipoprotein p53-up-regulated modulator of apoptosis Phosphoinositide 3-kinase Phospholipase C Platelet derived growth factor receptors Protein disulfide isomerase Protein kinase A Protein kinase C Ras homolog gene family member A Reactive oxygen species Receptor for advanced glycation end products
Chen J. et al.
Rho-GDIα ROCK STAT-3 SM-α-actin SS TAZ TGF-β1 TRPV TLR VSMC YAP
Rho GDP
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