C-reactive protein in traditional melanesians on Kitava
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C‑reactive protein in traditional melanesians on Kitava Pedro Carrera‑Bastos1, Maelán Fontes‑Villalba1, Michael Gurven2, Frits A. J. Muskiet3, Torbjörn Åkerfeldt4, Ulf Lindblad5, Lennart Råstam6, Johan Frostegård7, Yinon Shapira8, Yehuda Shoenfeld9,10,11, Yvonne Granfeldt12, Kristina Sundquist1 and Tommy Jönsson1*
Abstract Background: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by meas‑ uring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. Methods: Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swed‑ ish controls (N = 83). Results: CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1—48 mg/L and Mdn 1.1 mg/L range 0.1—33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values
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