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First report of anaphylaxis: case report A 58-year-old woman, who had been receiving danazol for 8 years, received an initial treatment of C1 inhibitor 1000U for pharyngeal angioedema. She developed serious anaphylaxis with respiratory distress and shock [time to reaction onset not stated] and required intensive care. Approximately 1.5 years later, recurrence of laryngeal/pharyngeal angioedema was successfully treated with ecallantide. Cicardi M, et al. A patient with hereditary angiodema who experienced anaphylaxis in response to C1 esterase inhibitor is successfully treated with DX-88 (ecallantide), a potent human plasma kallikrein inhibitor: a case study. Molecular 801070622 Immunology 44: 160-161, No. 1-3, Jan 2007 [abstract] - Italy

» Editorial comment: A search of AdisBase, Medline and the WHO Adverse Drug Reactions database did not reveal any previous case reports of anaphylaxis associated with C1 inhibitor.

0114-9954/10/1146-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Reactions 7 Apr 2007 No. 1146

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