Cancer
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Editorial Board: P. R. Bernstein · A. Buschauer · U. Gether · J. A. Lowe · H. U. Stilz
Cancer Volume Editor: Robert H. Bradbury
With contributions by P. Angibaud · J. Arts · J. F. Blake · J. S. de Bono · D. H. Boschelli R. H. Bradbury · K. Van Emelen · D. W. End · P. C. Fong R. A. Galemmo Jr · C. Garcia-Echeverria · J. Hoffmann · P. ten Holte M. Janicot · D. L. Johnson · H. Koblish · E. R. Laird · J. Lyssikatos L. Mevellec · K. J. Moriarty · K. Paz · A. Sommer · T. K. Sawyer E. M. Wallace · T. C. Yeh · Z. Zhu
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Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the new topic-related series should cover all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In references Topics in Medicinal Chemistry is abbreviated Top Med Chem and is cited as a journal. Springer WWW home page: springer.com Visit the TIMC content at springerlink.com
Library of Congress Control Number: 2006935870
ISSN 1862-2461 ISBN-10 3-540-33119-0 Springer Berlin Heidelberg New York ISBN-13 978-3-540-33119-3 Springer Berlin Heidelberg New York DOI 10.1007/978-3-540-33120-9
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com c Springer-Verlag Berlin Heidelberg 2007 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: KünkelLopka GmbH, Heidelberg Typesetting and Production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper 02/3100 YL – 5 4 3 2 1 0
Volume Editor Dr. Robert H. Bradbury AstraZeneca Pharmaceuticals Mereside 3S111, SK 10 4TG Macclesfield, Cheshire United Kingdom
Editorial Board Dr. Peter R. Bernstein
Prof. John A. Lowe
AstraZeneca Pharmaceuticals 1800 Concord Pike Fairfax Research Center B313 PO Box 15437 Wilmington, DE 19850-5437 USA
Pfizer Inc. MS
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