Changes of QTc interval after opioid switching to oral methadone
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ORIGINAL ARTICLE
Changes of QTc interval after opioid switching to oral methadone Sebastiano Mercadante & Giovanna Prestia & Claudio Adile & Alessandra Casuccio
Received: 4 April 2013 / Accepted: 31 July 2013 / Published online: 15 August 2013 # Springer-Verlag Berlin Heidelberg 2013
Abstract A consecutive sample of patients who were switched from strong opioids to methadone in a period of 1 year was surveyed. QTc was assessed before switching (T0) and after achieving adequate analgesia and an acceptable level of adverse effects (Ts). Twenty-eight of 33 patients were switched to methadone successfully. The mean initial methadone doses at T0 were 67.1 mg/day (SD ±80.2, range 12– 390). The mean QTc interval at T0 was 400 ms (SD ±30, range 330–450). The mean QTc interval at Ts (median 5 days) was 430 ms (SD ±26, range 390–500). The difference (7.7 %) was significant (p
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