Changes of the postcentral cortex in irritable bowel syndrome patients
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ORIGINAL RESEARCH
Changes of the postcentral cortex in irritable bowel syndrome patients Jiaofen Nan 1 & Wenya Yang 1 & Panting Meng 1 & Wei Huang 1 & Qian Zheng 1 & Yongquan Xia 1 & Feng Liu 2
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract The postcentral cortex (poCC) is commonly found to respond to visceral stimulation, but researchers usually pay less attention to this role of the poCC in the patients with functional gastrointestinal disorders, because it is a primary receptor for general bodily feeling of touch, such as temperature and pain. The current study focuses on the changes around the poCC in irritable bowel syndrome (IBS) patients based on the resting-state functional magnetic resonance imaging, aiming to investigate whether the poCC-centric brain metrics may be directly related to visceral perception. In the study, we calculated the regional homogeneity, seed-based correlation (SBC) and nodal centralities of the poCC to explore the changes in the regional activity and information flow around the poCC in IBS patients. Moreover, we examined the performance of the poCC-centric features in classifying the IBS group and healthy group in comparison to those features unrelated to the poCC. The results found that central alterations around the poCC in IBS patients were associated with the level of visceral pain, and exhibited a better discriminative power than those around the whole brain and the insula when classifying the IBS group and healthy group. In conclusion, the preliminary investigation provided fundamental advances in understanding the roles of the poCC in the pathphysiology of the IBS. Keywords Brain . Classification . Functional magnetic resonance imaging . Irritable bowel syndrome . Postcentral cortex
Introduction Irritable bowel syndrome (IBS) is one of the most common visceral pain, typified by the presence of not necessarily consecutive, but persistent abdominal pain or discomfort, accompanied by the changes of defecation (frequency or appearance) (Drossman and Dumitrascu 2006). According to the studies published over the recent two decades, multiple factors (emotion, stress, cognition, salience appraisal, memories of past experiences, reward processes, prediction of future experiences, inflammatory, visceral hypersensitivity, abnormal motility and genetic) contribute to the conscious experience of * Jiaofen Nan [email protected] * Yongquan Xia [email protected] 1
School of Computer and Communication Engineering, Zhengzhou University of Light Industry, No.136, Science Avenue, Zhengzhou 450000, Henan-Province, People’s Republic of China
2
School of Information Technology and Electrical Engineering, University of Queensland, QLD, Brisbane 4072, Australia
visceral pain (Mayer et al. 2015). The myriad sensory signals caused by multiple factors can be integrated into the brain in many ways, ultimately determining one’s subjective experience. However, the integral cortical and subcortical regions involvement in sensory signal integration, evaluation and mod
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