Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in
- PDF / 230,128 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 13 Downloads / 156 Views
ORIGINAL ARTICLE
Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures Marwa Elhady 1 & Eman R Youness 2 & Mones M. AbuShady 3 & Maysa S. Nassar 3 & Ali Abd Elaziz 3 & Mahmoud M Masoud 2 & Fayez K. Foudaa 2 & Walaa Alshasrany Abu Elhamed 4 Received: 27 April 2020 / Accepted: 5 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Epilepsy is a common neurological disease that has a negative impact on physical, social, and cognitive function. Seizure-induced neuronal injury is one of the suggested mechanisms of epilepsy complications. We aimed to evaluate the circulating level of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) as markers of neuronal damage in children with epilepsy and its relation to epilepsy characteristics. Study design Methods This case control study included 30 children with epilepsy and 30 healthy children as a control group. Seizure severity was determined based on Chalfont score. Serum level of GFAP and UCH-L1were measured, and their associations with epilepsy characteristics were investigated. Results Circulating levels of GFAP and UCH-L1 were significantly higher in children with epilepsy than in controls (17.440 ± 6.74 and 5.700 ± 1.64 vs 7.06 ± 3.30 and 1.81 ± 0.23, respectively) especially in those with generalized and active seizures. GFAP and UCH-L1 were significantly correlated to the severity of seizures in the previous 6 months. Elevated GFAP level was a predictor for active seizures (OR 1.841, 95%CI 1.043–3.250, P = 0.035). Conclusion Circulating GFAP and UCH-L1 expression is increased in children with epilepsy especially those with active seizures. Significance GFAP and UCH-L 1may serve as peripheral biomarkers for neuronal damage in children with epilepsy that can be used to monitor disease progression and severity for early identification of those with drug-resistant epilepsy and those who are in need for epilepsy surgery. Keywords Epilepsy . GFAP . UCH-L1 . Children
* Marwa Elhady [email protected]; [email protected]
Fayez K. Foudaa [email protected] Walaa Alshasrany Abu Elhamed [email protected]
Eman R Youness [email protected] Mones M. AbuShady [email protected]
1
Pediatric Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11735, Egypt
Maysa S. Nassar [email protected]
2
Medical Biochemistry Department, National Research Centre, Cairo, Egypt
Ali Abd Elaziz [email protected]
3
Child Health Department, National Research Centre, Cairo, Egypt
4
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
Mahmoud M Masoud [email protected]
Childs Nerv Syst
Introduction Epilepsy is a common neurological disease affecting about 1% of the general population with long-term sequels that may extend even after elimination of active seizures. It is characterized by recurrent seizures caused by hypers
Data Loading...
