Clinical experience with online motion-corrected stress and rest first pass myocardial perfusion images
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BioMed Central
Poster presentation
Clinical experience with online motion-corrected stress and rest first pass myocardial perfusion images
Open Access
Sujata M Shanbhag*, Christine Mancini, W Patricia Bandettini, Li-Yueh Hsu, Peter Kellman and Andrew E Arai Address: National Institutes of Health, Bethesda, MD, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P101
doi:10.1186/1532-429X-12-S1-P101
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P101 © 2010 Shanbhag et al; licensee BioMed Central Ltd.
Introduction Myocardial first pass perfusion is useful in patients with known or suspected coronary arterial disease. However, the time to manually trace and correct myocardial regions of interest (ROIs) is a significant barrier to clinical workflow. This study tested time to analyze perfusion using an online (i.e. scanner acquired), fully automated, non-rigid, image registration perfusion method.
Purpose 1. To determine the time needed to analyze online, motion-corrected (MOCO) perfusion images versus raw non-motion corrected images. 2. To qualitatively review whether motion corrected images distort the appearance of abnormal perfusion images.
raw stress perfusion images in a patient with an anteroseptal perfusion defect. In the 20 stress perfusion studies, MOCO reduced overall analysis time by 28% (20:03 ± 07:33 to 14:24 ± 5:44, raw vs MOCO, p = 0.001) which was almost entirely due to less time needed to manually adjust ROIs (15:57 ± 7:36 to 10:28 ± 5:33, p = 0.001). MOCO reduced overall analysis time and manual adjustment time by a similar amount for the 20 rest perfusion studies (p < 0.001). To determine how well MOCO handled respiratory motion, we quantified analysis time in patients who were instructed not to hold their breath during the perfusion imaging. For non-breathhold stress perfusion imaging, overall analysis time was reduced from 18:35 ± 5:12 to 11:42 ± 3:11 (raw vs MOCO, p = 0.007) which was largely due to the a reduction in the time used to make manual
Methods 20 patients were studied on a 1.5 T Siemens Avanto using a first pass perfusion method that automatically aligns perfusion images on the console using a non-rigid image registration method. All patients were studied during dipyridamole stress and at rest. Half the patients were intentionally instructed not to hold their breath during the acquisition. The study endpoint was time to create and manually correct epicardial and endocardial regions of interest needed to create time intensity curves.
Results Qualitatively, MOCO perfusion images were essentially equivalent in image quality to the raw perfusion images. Figures 1 and 2 show an exampl
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