Clinical features of benign convulsions with mild gastroenteritis in Chinese infants
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Clinical features of benign convulsions with mild gastroenteritis in Chinese infants Yun-Feng Wang, Zhong-Shu Zhou Beijing, China
Methods: A retrospective study was conducted in 48 patients with convulsions between January 1, 2004 and December 31, 2009. Results: The age of onset of gastroenteritis was between 13 months and 24 months in 34 patients (70.83%). The episodes occurred at a distinct autumn/ winter peak (75%). The seizures mostly occurred within the first 5 days of gastroenteritis, especially within the first 3 days, peaking on day 2 (39.58%). Thirtyfive patients (72.92%) had clustered seizures in their episodes. Most episodes were symmetric, generalized tonic–clonic (83.33%) and brief (93.75%). The seizures were induced by pain and/or crying in 19 (39.58%) patients. Stool culture was positive for rotavirus in 21 (53.85%) of the 39 patients. Twenty patients (20/41, 48.78%) still had clustered seizures after the administration of a single anticonvulsant. The seizures persisted even after the administration of two combined anticonvulsants in 5 (26.32%) of 19 episodes. All patients exhibited normal psychomotor development. Conclusions: Benign convulsions with mild gastroenteritis are not rare in China, and rotavirus infection is a major cause. World J Pediatr 2013;9(1):73-75 Key words: gastroenteritis; infant; seizure
Author Affiliations: Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China (Wang YF, Zhou ZS) Corresponding Author: Zhong-Shu Zhou, Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China (Tel: +86-10-84206180; Email: [email protected]) doi: 10.1007/s12519-012-0393-x ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2012. All rights reserved.
Introduction
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enign convulsions with mild gastroenteritis (CwG) occur in infants during the course of mild gastroenteritis. This condition is characterized by: (1) afebrile generalized seizures associated with symptoms of gastroenteritis in previously healthy children aged between 6 months to 3 years; (2) seizures often occurring in clusters; (3) mild dehydration (less than 5% of body weight); (4) normal laboratory examination results including electrolytes, blood glucose and cerebrospinal fluid; (5) normal interictal electroencephalography; and (6) always a good prognosis without sequelae.[1,2] CwG was firstly reported in Japan,[1,3,4] and now the condition is recognized not only in Asian areas,[5,6] but also in the United States [7] and some European countries. [8-10] However, the occurrence of CwG in China has not yet been widely recognized by Chinese pediatricians with only a few reports.[11] The disease can easily be mistaken for meningitis or encephalitis and can, therefore, result in unnecessary treatment. In the present study, we firstly described in detail the clinical, electroencephalographic and etiologic features of 48 patients with CwG in China.
Methods
A retrospective study was conducted in 48 children with CwG who were hospitalized at the Chi
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