Clinical manifestations of COVID-19 in the general population: systematic review
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Wien Klin Wochenschr https://doi.org/10.1007/s00508-020-01760-4
Clinical manifestations of COVID-19 in the general population: systematic review Rodrigo da Rosa Mesquita · Luiz Carlos Francelino Silva Junior · Fernanda Mayara Santos Santana · Tatiana Farias de Oliveira · Rafaela Campos Alcântara · Gabriel Monteiro Arnozo · Etvaldo Rodrigues da Silva Filho · Aisla Graciele Galdino dos Santos · Euclides José Oliveira da Cunha · Saulo Henrique Salgueiro de Aquino · Carlos Dornels Freire de Souza Received: 6 August 2020 / Accepted: 19 October 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Summary Clinical manifestations of COVID-19 are varied in the general population. This study aimed to systematize the literature regarding clinical manifestations of patients with confirmed COVID-19. A systematic review of the literature was conducted. A total of 8070 scientific productions were found in the databases. Among the studies, 184 met the initial inclusion criteria, with a total of 114,046 patients. After complete reading, 32 studies that did not report clinical manifestations were excluded. The 152 publications finally included a total of 41,409 individuals from at least 23 countries and 26 different clinical manifestations were reported. In percentage terms, 6 symptoms had a general prevalence greater than or equal to 25%, namely, fever (58.66%), cough (54.52%), dyspnea (30.82%), malaise (29.75%), fatigue (28.16%) and sputum/secretion (25.33%). Neurological symptoms (20.82%), dermatological manifestations (20.45%), anorexia (20.26%), myalgia (16.9%), sneezing (14.71%), sore throat (14.41%), rhinitis (14.29%), goosebumps (13.49%), headache (12.17%), chest pain (11.49%) and diarrhea (9.59%) were other
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00508-020-01760-4) contains supplementary material, which is available to authorized users. R. da Rosa Mesquita · L. C. Francelino Silva Junior · F. M. Santos Santana · T. Farias de Oliveira · R. Campos Alcântara · G. Monteiro Arnozo · E. Rodrigues da Silva Filho · A. G. Galdino dos Santos · E. J. Oliveira da Cunha · S. H. Salgueiro de Aquino · C. D. Freire de Souza () Department of Medicine, Federal University of Alagoas, Arapiraca, Brazil [email protected] C. D. Freire de Souza Campus Arapiraca, Rodovia AL-115, Bom Sucesso, Federal University of Alagoas, 57309-005 Arapiraca, Alagoas, Brazil
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common symptoms. Only one study reported dermatological manifestations. The least frequent sign/ symptom was hemoptysis (1.65%). In studies with more than 100 patients, the 3 main symptoms were fever (57.93%), cough (54.21%), and dyspnea (30.64%). Dermatological manifestations do not appear among the main symptoms. The identification of all clinical manifestations of COVID-19 is essential for an early diagnosis and the adoption of preventive measures. Keywords Coronavirus infection · Epidemiology · SARS virus · General symptoms
Introduction In late 2019 the first cases of pneumonia of unknown etiology we
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