Clinicopathological and molecular characteristics associated with PD-L1 expression in non-small cell lung cancer: a larg
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ORIGINAL ARTICLE – CLINICAL ONCOLOGY
Clinicopathological and molecular characteristics associated with PD‑L1 expression in non‑small cell lung cancer: a large‑scale, multi‑center, real‑world study in China Qiang Zheng1,2 · Yan Huang3 · Xin Zeng4 · Xiaoyan Chen5 · Shihong Shao6 · Yan Jin1,2 · Qianqian Xue1,2 · Yue Wang1,2 · Yan Guo7 · Bin Gu7 · Chunyan Wu3 · Yuan Li1,2 Received: 3 September 2020 / Accepted: 27 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The study aimed to evaluate the clinicopathological and molecular profiles associated with programmed death ligand 1 (PD-L1) expression in non-small cell lung cell (NSCLC) in a large-scale, multi-center, real-world Chinese cohort. Methods A total of 6295 NSCLC specimens from six centers in China were analyzed by PD-L1 (22C3) assay. PD-L1 expression in tumor cells (TCs) was classified as negative (TPS expression in
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