Combinatorial Chemistry in Biology
The essence of combinatorial chemistry or techniques involving "molecular diversity" is to generate enormous populations of molecules and to exploit appropriate screening techniques to isolate active components contained in these libraries. This idea has
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Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama J.M. Hogle, Boston/Massachusetts· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Me1chers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La Jolla/California· H. Wagner, Munich
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Combinatorial Chemistry in Biology Edited by M. Famulok, E.-L. Winnacker, and C.-H. Wong
With 48 Figures and 8 Tables
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Springer
Professor Dr. MICHAEL FAMULOK Kekule-Institut ffir Organische Chemie und Biochemie Gerhard-Domagk-Str. 1 D-53121 Bonn Germany Professor Dr. ERNST-L. WINNACKER Ludwig Maximilians Universitat Mfinchen Institut fUr Biochemie - Genzentrum Feodor-Lynnen-Str. 25 D-81377 Mfinchen Germany Professor Dr. CHI-HUEY WONG The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 USA
Cover Illustration: "The cover shows a chalk-drawing on a blackboard symbolizing the principle of randomization and selection by successively selecting patterns on the face of dices. The cover was generated by Boris Steipe and Iris Haussler, BioLink GmbH, Martinsried." Cover Design: design & production GmbH, Heidelberg ISSN 0070-217X ISBN-13: 978-3-642-64274-6 e-ISBN-13: 978-3-642-60142-2 DOl: 10.1007/978-3-642-60142-2 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1999
Library of Congress Catalog Card Number 15-12910 Softcover reprint of the hardcover 1st edition 1999 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Pmduct liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting other relevant literature. Typesetting: Scientific Publishing Services (P) Ltd, Madras Production Editor: Angelique Gcouta SPIN: 10679885
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Preface
The essence of combinatorial chemistry or techniques involving "molecular diversity" is to generate enormous populations of molecules and to exploit appropriate screening techniques to isolate active components contained in these libraries. This idea has been the focus of research
