Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the t
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Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects Monali Shah • Astrid Lobo Gajiwala Sneha Shah • Deepak Dave
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Received: 28 May 2014 / Accepted: 28 October 2014 Ó Springer Science+Business Media Dordrecht 2014
Abstract Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. Questions have been raised however, about the osteogenic potential of the variety of grafts available. In India the cost factor is another important consideration. The aim of this study therefore was to evaluate the clinical efficiency of the low priced, indigenously prepared DFDBA obtained from the Tata Memorial Hospital (TMH) Tissue Bank, in periodontal regeneration in infrabony periodontal defects, as compared to DFDBA obtained from the Pacific Coast Tissue Bank (DEMBONE). The latter was used as the control. 16 patients with bilaterally similar periodontal infrabony defects were selected, and randomly allotted to the test and control groups. At baseline, using standardized protocol, recession, probing depths (PD), and clinical attachment levels (CAL) were measured, following which periodontal surgery was carried out, with placement of the respective graft materials. Patients were recalled after 6 months for re-assessment. Statistically significant improvement was obtained for PD reduction and CAL gain for both
groups (p \ 0.05). However, no significant difference was observed between the test and control groups. It was therefore concluded that both the materials from different tissue banks are equally effective clinically, with the test material being additionally cost effective. Keywords DFDBA Demineralized freeze dried bone allograft DEMBONE Tata Memorial Hospital Tissue Bank Periodontal regeneration Periodontal infrabony defects Abbreviations DFDBA Demineralized freeze-dried bone allograft TMH Tata Memorial Hospital OFD Open flap debridement LA Local anesthesia PD Probing depth CAL Clinical attachment level BMP Bone morphogenetic protein
Introduction M. Shah S. Shah (&) D. Dave Department of Periodontics, K. M. Shah Dental College and Hospital, Vadodara, India e-mail: [email protected] A. Lobo Gajiwala Tissue Bank, Tata Memorial Hospital, Dr. E. Borges Road, Mumbai 400 012, India e-mail: [email protected]
Periodontal therapy aims at arresting the disease process, preventing disease recurrence, and regenerating lost periodontium. Bone grafts, guided tissue regeneration, and application of growth factors are currently used for periodontal regeneration in the treatment of infrabony defects (American Academy of Periodontology 2001; Darby 2011).
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Predictable bone regeneration involves restoring lost supporting structures of the dentition such as cementum, periodontal ligament and bone, to the diseased root surface (Abolfazli et al. 2008). Several studies have demonstrated that the use of graft materials give better clinical results when com
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