Comparison of deconvoluted plasma DSC curves on patients with solid tumors
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Comparison of deconvoluted plasma DSC curves on patients with solid tumors Dénes Lőrinczy1 · Andrea Ferencz2 Received: 2 August 2019 / Accepted: 11 February 2020 © The Author(s) 2020
Abstract Today, differential scanning calorimetry (DSC) has increasingly been an accepted method for diagnosing and monitoring different diseases. Moreover, as a highly sensitive technique it seems to be applicable in human cancer researches. Our workgroup in several previous researches has already demonstrated marked differences on DSC plasma profiles between healthy control and various tumorous patients and, in addition, at their different stages. The aim of this study was to compare deconvoluted plasma DSC curves on patients with solid tumors. Blood plasma DSC data were analyzed retrospectively from various patients, who has only local cancer diseases (malignant melanoma: n = 15, breast carcinoma: n = 10 and pancreas adenocarcinoma: n = 11) without any regional or distant metastases. The complex curves were deconvoluted in numerous individual transitions (five or seven melting points). In the examined patients with solid tumors, the thermodynamic parameters: heat flow and calorimetric enthalpy of the transitions corresponding to the most abundant plasma proteins, as well as the numbers of transitions were determined from the calorimetric profiles. Deconvoluted DSC curves from blood samples of patients showed differences and similarities at the same time in the thermal denaturation of plasma components in various carcinoma cases. Keywords Solid tumors · Blood plasma · DSC · Curve · Deconvolution
Introduction According to the survey of World Health Organization (WHO), cancer is the second leading cause of death globally and is responsible for an estimated 9.6 million deaths in 2018 [1]. Based on the WHO GLOBOCAN (Global Cancer) database, breast cancer is the third, melanoma malignum (MM) is the fifth, while pancreas adenocarcinoma is the twelfth in terms of incidence and these malignant diseases are ranked within the top twenty in terms of mortality [2]. Basically, these solid tumors have two major types of groups: sarcomas and carcinomas. Many types of solid * Andrea Ferencz [email protected] Dénes Lőrinczy [email protected] 1
Institute of Biophysics, Medical School, University of Pécs, Pecs, Szigeti Str. 12, Hungary
Department of Surgical Research and Techniques, Medical Faculty, Semmelweis University, Budapest, Nagyvárad Sqr. 4, 1089, Hungary
2
tumors are often treated with surgery. But, next to the type and stage of tumors during treatment decision making for cancer takes into account risks contra benefits of planned therapy, and treatment should be supplemented with postoperative chemo- and/or radiotherapy, or with targeted biological treatment or multimodal therapy if these are available for that cancer type [3]. Blood samples examination is still a noninvasive detection and monitoring method during cancer research and patient care also. Today, among the features that can be detected in blood only the tum
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