Concurrent alterations of white matter microstructure and functional activities in medication-free major depressive diso
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ORIGINAL RESEARCH
Concurrent alterations of white matter microstructure and functional activities in medication-free major depressive disorder Min Zeng 1 & Min Yu 2 & Guiqiang Qi 1 & Shaojin Zhang 1 & Jijian Ma 1 & Qingmao Hu 3,4 & Jinhuan Zhang 3,5 & Hongxing Li 2 & Huawang Wu 6 & Jinping Xu 3 Received: 28 May 2020 / Revised: 18 August 2020 / Accepted: 14 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Although numerous studies have revealed the structural and functional alterations in major depressive disorder (MDD) using unimodal diffusion magnetic resonance imaging (MRI) or functional MRI, however, the potential associations between changed microstructure and corresponding functional activities in the MDD has been largely uninvestigated. Herein, 27 medication-free MDD patients and 54 gender-, age-, and educational level-matched healthy controls (HC) were used to investigate the concurrent alterations of white matter microstructure and functional activities using tract-based spatial statistics (TBSS) analyses, fractional amplitude of low-frequency fluctuation (fALFF), and degree centrality (DC). The TBSS analyses revealed significantly decreased fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF I) in the MDD patients compared to HC. Correlation analyses showed that decreased FA in the SLF I was significantly correlated with fALFF in left pre/postcentral gyrus and binary, weighted DC in right posterior cerebellum. Moreover, the fALFF in left pre/postcentral gyrus significantly reduced in MDD patients while binary and weighted DC in right posterior cerebellum significantly increased in MDD patients. Our results revealed concurrent structural and functional changes in MDD patients suggesting that the underlying structural disruptions are an important indicator of functional abnormalities. Keywords Major depressive disorder . Tract-based spatial statistics . Fractional amplitude of low-frequency fluctuation . Degree centrality . Resting-state functional magnetic resonance imaging
Introduction Major depressive disorder (MDD) is a pervasive psychiatric disorder with high lifetime prevalence, which has become the second leading cause for chronic disease burden (Kupfer et al. 2012). In order to uncover the neural basis of MDD, many studies have been performed to investigate the white matter
microstructure and functional alterations using diffusion tensor imaging (DTI) (Chen et al. 2016a, b, c; Coloigner et al. 2019; Davis et al. 2019; Jiang et al. 2017; Wang et al. 2014) and resting-state functional magnetic resonance imaging (rs-fMRI) (Depping et al. 2018; Huang et al. 2017; Ries et al. 2019; Wang et al. 2017a, b, c, 2018a, b, 2019a, b, c; Sun et al. 2018). Structurally, previous studies have identified widespread white
Min Zeng and Min Yu contibuted equally to this work. * Hongxing Li [email protected] * Huawang Wu [email protected]
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Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Scien
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