Consensus Recommendations on GLP-1 RA Use in the Management of Type 2 Diabetes Mellitus: South Asian Task Force

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Consensus Recommendations on GLP-1 RA Use in the Management of Type 2 Diabetes Mellitus: South Asian Task Force Sanjay Kalra . Ashok Kumar Das . Rakesh Kumar Sahay . Manash Pratim Baruah . Mangesh Tiwaskar . Sambit Das . Sudip Chatterjee . Banshi Saboo . Ganapathi Bantwal . Saptarshi Bhattacharya . Gagan Priya . Manoj Chawla . Kiraninder Brar . Syed Abbas Raza . Azizul Hasan Aamir . Dina Shrestha . Noel Somasundaram . Prasad Katulanda . Faria Afsana . Shahjada Selim . Mohammad Wali Naseri . Ali Latheef . Manilka Sumanatilleke Received: March 7, 2019  The Author(s) 2019

ABSTRACT The advent of incretin mimetics such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has enriched the armamentarium for diabetes management owing to their glycaemic as well as extra-glycaemic benefits. The approval status and availability of this class of drugs vary widely

Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.8850866. Electronic Supplementary Material The online version of this article (https://doi.org/10.1007/s13300019-0669-4) contains supplementary material, which is available to authorized users. S. Kalra (&) Bharti Hospital, Karnal, India e-mail: [email protected] A. K. Das Pondicherry Institute of Medical Sciences, Pondicherry, India R. K. Sahay Osmania Medical College, Hyderabad, India M. P. Baruah Excelcare Hospitals, Guwahati, India M. Tiwaskar Karuna Hospital, Mumbai, India S. Das Hi Tech Medical College and Hospital, Bhubaneshwar, India

across the globe. Being a relatively newer class of drug with numerous benefits, several national and international guidelines are working towards addressing clinical questions pertaining to the optimal use of GLP-1 RAs for the management of diabetes. Although the newer class of drugs are associated with significant benefits such as patient-centric approach, these drugs demand the providers to be vigilant and knowledgeable about the medication. The South Asian population is at higher risk of type 2 diabetes mellitus (T2DM) because of their genetic predisposition and lifestyle changes. Hence, prevention and management of T2DM and its associated complications in this population are of paramount importance. The current report aims to present an overview of S. Chatterjee Park Clinic, Kolkata, India B. Saboo Dia Care, Ahmedabad, India G. Bantwal St John’s Medical College, Bangalore, India S. Bhattacharya Max Super Speciality Hospital, Delhi, India G. Priya Fortis Hospital, Mohali, India M. Chawla BSES MG Hospital, Mumbai, India K. Brar Army Research and Referral Hospital, Delhi, India

Diabetes Ther

current knowledge on GLP-1 RAs based on pragmatic review of the available clinical evidence. In addition, this report is a consensus of expert endocrinologists representing South Asian countries including India, Pakistan, Bangladesh, Nepal, Sri Lanka, Afghanistan and the Maldives on essential recommendations related to the use of GLP-1 RAs in a real-world scenario.

Keywords: Calorie restriction mimetics