Correction to: Pharmacokinetics and Dialyzability of a Single Oral Dose of Amenamevir, an Anti-Herpes Drug, in Hemodialy
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CORRECTION
Correction to: Pharmacokinetics and Dialyzability of a Single Oral Dose of Amenamevir, an Anti-Herpes Drug, in Hemodialysis Patients Shuichi Tsuruoka . Takamasa Endo
. Mizuna Seo . Naoto Hashimoto
Published online: September 15, 2020 Ó The Author(s) 2020 Correction to: Adv Ther (2020) 37:3234–3245 https://doi.org/10.1007/s12325-020-01375-1
In the original article, there is incorrect text has published as ‘‘The hemodialysis clearance, elimination fraction percentage, and amount of amenamevir removed were 37.8 mL/min, 28.1%, and 132.0 lg, respectively’’. The correct text is ‘‘The hemodialysis clearance, elimination fraction percentage, and amount of amenamevir removed were 41.4 mL/min, 30.7%, and 7919 lg, respectively’’.
The original article can be found online at https://doi. org/10.1007/s12325-020-01375-1. S. Tsuruoka Department of Nephrology, Nippon Medical School, Tokyo, Japan T. Endo (&) M. Seo Clinical Development Department, Maruho Co., Ltd, Kyoto, Japan e-mail: [email protected] N. Hashimoto Drug Development Research Laboratory, Maruho Co., Ltd, Kyoto, Japan
The incorrect text has published as ‘‘There was no correlation between CLHD and Kt/V (A), but a strong negative correlation between EP and Kt/V (r = - 0.75) (C) was found, whereas the amount removed was positively correlated with Kt/V (r = 0.55) (E)’’. The correct text is ‘‘There was no correlation between CLHD and Kt/V (A), but a strong negative correlation between EP and Kt/V (r = - 0.77) (C) was found, whereas the amount removed was positively correlated with Kt/V (r = 0.58) (E)’’.
Adv Ther (2020) 37:4758–4764
4759
Original Table Table 4 Hemodialysis parameters of amenamevir and its major metabolite R5 (n = 9) Amenamevir
R5
Mean (SD)
Mean (SD)
Median Min–max
Median Min–max
Hemodialysis clearance (mL/min)
37.8 (5.3)
37.5
30.9–48.0
46.5 (4.4)
45.0
41.4–56.2
Hemodialysis clearance normalized with dialyzer surface area (mL/min/m2)
22.7 (5.4)
22.8
15.1–32.3
28.2 (7.4)
27.6
18.2–40.8
Elimination fraction percentage (%)
28.1 (5.1)
27.4
22.2–36.6
34.5 (4.7)
32.5
29.6–42.9
Removed amount (lg)
132.0 131.6 (54.2)
43.4–236.8 65.1 69.6 (28.7)
23.7–121.4
Max maximum; Min minimum, SD standard deviation
Corrected Table Table 4 Hemodialysis parameters of amenamevir and its major metabolite R5 (n = 9) Amenamevir
R5
Mean (SD)
Median Min–max
Mean (SD)
Median Min–max
Hemodialysis clearance (mL/min)
41.4 (5.0)
39.6
35.7–52.2
49.8 (4.6)
49.3
45.3–60.0
Hemodialysis clearance normalized with dialyzer surface area (mL/min/m2)
24.9 (5.9)
24.9
17.0–35.0
30.1 (7.9)
30.2
19.7–43.3
Elimination fraction percentage (%)
30.7 (4.8)
29.3
25.5–38.6
36.8 (4.5)
35.6
32.3–44.7
Removed amount (lg)
7919 7894 (3253)
2602–14,210 3905 4177 (1722)
1419–7282
Max maximum, Min minimum, SD standard deviation
Adv Ther (2020) 37:4758–4764
4760
Original Figure
B
50
Hemodialysis clearance (mL/min/m2)
Hemodialysis clearance (mL/min/m2)
A
45 40 35 30 25 20 15
y = 2.5122x + 25.465 R² = 0.0041
10 5 0
0
0
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