Cortical morphometry alterations in brain regions involved in emotional, motor-control and self-referential processing i
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ORIGINAL RESEARCH
Cortical morphometry alterations in brain regions involved in emotional, motor-control and self-referential processing in patients with functional constipation Chunxin Hu 1 & Li Liu 1 & Lei Liu 1 & Junwang Zhang 2 & Yang Hu 1 & Wenchao Zhang 1 & Yueyan Ding 1 & Yuanyuan Wang 1 & Zhida Zhang 1 & Karen M. von Deneen 1 & Long Qian 3 & Huaning Wang 4 & Shijun Duan 5 & Fan Wang 6 & Guangbin Cui 5 & Yongzhan Nie 2 & Yi Zhang 1
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Functional constipation (FC) is a common functional gastrointestinal disorder (FGID). Neuroimaging studies on patients with FC showed brain functional abnormalities in regions involved in emotional process modulation, somatic and sensory processing and motor control. Brain structural imaging studies in patients with FGID have also shown disease-related alterations in cortical morphometry, but whether and how FC affects brain structure remains unclear. Structural Magnetic Resonance Imaging and surface-based morphometry analysis were used to investigate the impact of FC on cortical morphometry in 29 patients with FC and 29 healthy controls (HC). Results showed that patients with FC compared to HC had significantly decreased cortical thickness in the left middle frontal gyrus (MFG), dorsomedial (DMPFC) and ventromedial prefrontal gyrus (VMPFC), right dorsal anterior cingulate cortex (dACC), left orbitofrontal cortex (OFC), posterior cingulate cortex (PCC)/precuneus, middle temporal gyrus (MTG), and supplementary motor area (SMA) (P < 0.01). Correlation analysis showed that sensation of incomplete evacuation was negatively correlated with cortical thickness in the SMA (P < 0.0001). In addition, patients with FC also had decreased cortical volume than HC in the MTG, precentral gyrus (PreCen) and precuneus/cuneus (P < 0.01), as well as decreased cortical surface area in the PreCen (P < 0.01). No correlation was found between cortical volume/surface area and behavioral measures. These findings suggest that patients with FC are associated with cortical morphometric abnormalities in brain regions implicated in somatic/motor-control, emotional processing and self-referential processing. Keywords Functional constipation . Structural MRI . Cortical morphometry . Orbitofrontal cortex . Anterior cingulate cortex
Introduction Functional constipation (FC) is a common functional gastrointestinal disorder (FGID) (Alame and Bahna 2012; De * Guangbin Cui [email protected] * Yongzhan Nie [email protected]
Giorgio et al. 2015; Koppen et al. 2015), with a prevalence ranging from 9.7 to 29.6% (Levy et al. 2017; Mugie et al. 2011) and a mean female to male ratio of 2.1:1 (Mugie et al. 2011). FC is characterized by infrequent bowel movements, 3
Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
4
Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
5
Department of Radiology, Tangdu Hospital, Fourth Mi
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