Cyclic Peptide Design
This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptid
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Gilles Goetz Editor
Cyclic Peptide Design
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cyclic Peptide Design Edited by
Gilles Goetz Hit Discovery and Optimization, Pfizer R&D, Groton, CT, USA
Editor Gilles Goetz Hit Discovery and Optimization Pfizer R&D Groton, CT, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9503-5 ISBN 978-1-4939-9504-2 (eBook) https://doi.org/10.1007/978-1-4939-9504-2 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface If you are used to the Methods in Molecular Biology series, you will notice right away that there are very few methods and virtually no molecular biology in this particular edition. This book will certainly stand out in your collection. Very few chapters of this book are written in the typical MiMB format, but this does not take anything away from the value of the works presented here! Interests in cyclic peptide design, synthesis, and applications keep growing since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. Cyclic peptides are particularly suited to bridge the chemical space gap between said small molecules and proteins and antibodies. This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognitio
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